Iciar Arteagoitia1, Eva Ramos2, Gorka Santamaria1, Luis Barbier3, Julio Alvarez3, Joseba Santamaria4. 1. Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain. 2. College of Pharmacists, Vizcaya, Spain. 3. Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain; Maxillofacial Group, BioCruces Health Research Institute, Cruces University Hospital, Vizcaya, Spain. 4. Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain; Maxillofacial Group, BioCruces Health Research Institute, Cruces University Hospital, Vizcaya, Spain. Electronic address: Jsz@clinicaimd.com.
Abstract
OBJECTIVE: The purpose of this study was to determine the effect of amoxicillin/clavulanic acid to prevent infection following completely bone-impacted lower third molar removal. STUDY DESIGN: A random, double-blind placebo-controlled clinical trial including 118 adults randomly allocated toplacebo (60 patients) or antibiotic treatment (58 patients): 2 g amoxicillin/125 mg clavulanic acid 2 hours before the surgery and post-operatively twice a day for 4 days. Infection was clinically assessed until 8 weeks after surgery. Adverse events, as well as clinical and surgical variables, were recorded. Analysis was by intention to treat. RESULTS:Infections developed in five patients in the placebo group, all in the first postoperative week, and in two in the antibiotic group, both after the first week, the difference not being statistically significant (P = .278, number needed to treat 19 [8-∞]). There were no relationships between any variables studied and infection. No serious adverse events were reported. CONCLUSION: There is insufficient evidence to recommend routine use of this antibiotic treatment.
RCT Entities:
OBJECTIVE: The purpose of this study was to determine the effect of amoxicillin/clavulanic acid to prevent infection following completely bone-impacted lower third molar removal. STUDY DESIGN: A random, double-blind placebo-controlled clinical trial including 118 adults randomly allocated to placebo (60 patients) or antibiotic treatment (58 patients): 2 g amoxicillin/125 mg clavulanic acid 2 hours before the surgery and post-operatively twice a day for 4 days. Infection was clinically assessed until 8 weeks after surgery. Adverse events, as well as clinical and surgical variables, were recorded. Analysis was by intention to treat. RESULTS: Infections developed in five patients in the placebo group, all in the first postoperative week, and in two in the antibiotic group, both after the first week, the difference not being statistically significant (P = .278, number needed to treat 19 [8-∞]). There were no relationships between any variables studied and infection. No serious adverse events were reported. CONCLUSION: There is insufficient evidence to recommend routine use of this antibiotic treatment.
Authors: Giovanni Lodi; Lorenzo Azzi; Elena Maria Varoni; Monica Pentenero; Massimo Del Fabbro; Antonio Carrassi; Andrea Sardella; Maddalena Manfredi Journal: Cochrane Database Syst Rev Date: 2021-02-24
Authors: L Barbier; E Ramos; J Mendiola; O Rodriguez; G Santamaria; J Santamaria; I Arteagoitia Journal: Med Oral Patol Oral Cir Bucal Date: 2018-07-01
Authors: María-Iciar Arteagoitia; Eva Ramos; Gorka Santamaría; Julio Álvarez; Luis Barbier; Joseba Santamaría Journal: Med Oral Patol Oral Cir Bucal Date: 2016-01-01