Paul D Loprinzi1, Carlos J Crespo2, Ross E Andersen3, Ellen Smit4. 1. Department of Health, Exercise Science, and Recreation Management, School of Applied Sciences, The University of Mississippi, University, Mississippi. Electronic address: pdloprin@olemiss.edu. 2. School of Community Health, Portland State University, Portland. 3. Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada. 4. Program in Epidemiology, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon.
Abstract
BACKGROUND: Few studies have examined the underweight-morbidity relationship, and those that have were conducted in non-U.S. populations and limited in their evaluation of cardiovascular disease (CVD) risk factors. PURPOSE: To examine the associations among underweight (along with overweight and obese) and various CVD risk factors in a national sample of U.S. adults (aged ≥20 years). METHODS: Ten years of data (1999-2010) from the National Health and Nutrition Examination Survey were used (analyzed in 2014). Underweight (tertiles); overweight (25-29.9); and obesity (three classes: 30-34.9, 35-39.9, and ≥40) were assessed from measured BMI. The evaluated biological and anthropometric markers included waist circumference; mean arterial pressure; C-reactive protein (CRP); fasting low-density lipoprotein (LDL) cholesterol; total cholesterol; fasting triglycerides; and fasting glucose. RESULTS: After adjustments, underweight adults had significantly (p<0.005) lower levels of CRP (β=-0.12, Tertile 2); total cholesterol (β=-17.7 and -12.2, Tertiles 1 and 3); total cholesterol to high-density lipoprotein cholesterol ratio (β=-0.39 and -0.46, Tertiles 2 and 3); LDL cholesterol (β=-20.7, Tertile 1); and triglycerides (β=-37.1 and -18.0, Tertiles 1 and 3) compared to normal-weight individuals. The severely underweight and obese were less likely to be physically active than normal-weight adults (p<0.001). Adults in each of the overweight and obese groups had higher levels for each biomarker compared to normal-weight individuals. CONCLUSIONS: Underweight adults have lower (i.e., more favorable) levels of various CVD biomarkers.
BACKGROUND: Few studies have examined the underweight-morbidity relationship, and those that have were conducted in non-U.S. populations and limited in their evaluation of cardiovascular disease (CVD) risk factors. PURPOSE: To examine the associations among underweight (along with overweight and obese) and various CVD risk factors in a national sample of U.S. adults (aged ≥20 years). METHODS: Ten years of data (1999-2010) from the National Health and Nutrition Examination Survey were used (analyzed in 2014). Underweight (tertiles); overweight (25-29.9); and obesity (three classes: 30-34.9, 35-39.9, and ≥40) were assessed from measured BMI. The evaluated biological and anthropometric markers included waist circumference; mean arterial pressure; C-reactive protein (CRP); fasting low-density lipoprotein (LDL) cholesterol; total cholesterol; fasting triglycerides; and fasting glucose. RESULTS: After adjustments, underweight adults had significantly (p<0.005) lower levels of CRP (β=-0.12, Tertile 2); total cholesterol (β=-17.7 and -12.2, Tertiles 1 and 3); total cholesterol to high-density lipoprotein cholesterol ratio (β=-0.39 and -0.46, Tertiles 2 and 3); LDL cholesterol (β=-20.7, Tertile 1); and triglycerides (β=-37.1 and -18.0, Tertiles 1 and 3) compared to normal-weight individuals. The severely underweight and obese were less likely to be physically active than normal-weight adults (p<0.001). Adults in each of the overweight and obese groups had higher levels for each biomarker compared to normal-weight individuals. CONCLUSIONS: Underweight adults have lower (i.e., more favorable) levels of various CVD biomarkers.
Authors: Mohammad Ali; Shahana Jasmin; Mohammad Fariduddin; Sheikh M K Alam; M I Arslan; Subrata K Biswas Journal: Mol Biol Rep Date: 2018-07-28 Impact factor: 2.316
Authors: Anne-Christine Plank; Janina Maschke; Nicolas Rohleder; Peter A Fasching; Matthias W Beckmann; Johannes Kornhuber; Anna Eichler; Gunther H Moll; Oliver Kratz Journal: Front Immunol Date: 2021-12-16 Impact factor: 8.786