| Literature DB >> 2544221 |
J S Burns1, L Lemoine, N R Lemoine, E D Williams, D Wynford-Thomas.
Abstract
A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.Entities:
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Year: 1989 PMID： 2544221 PMCID： PMC2247228 DOI： 10.1038/bjc.1989.158
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640