Boback M Berookhim1, Gianpiero D Palermo2, Nikica Zaninovic2, Zev Rosenwaks2, Peter N Schlegel3. 1. Department of Urology, Weill Cornell Medical College, New York, New York; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. 2. Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York. 3. Department of Urology, Weill Cornell Medical College, New York, New York; The Population Council, Center for Biomedical Research, New York, New York. Electronic address: pnschleg@med.cornell.edu.
Abstract
OBJECTIVE: To study the outcomes of microdissection testicular sperm extraction (microTESE) among men with pure Sertoli cell-only histology on diagnostic testicular biopsy. DESIGN: Retrospective cohort study. SETTING: Tertiary referral center. PATIENT(S): Six hundred forty patients with pure Sertoli cell-only histology on testicular biopsy who underwent microTESE by a single surgeon. INTERVENTION(S): MicroTESE. MAIN OUTCOME MEASURE(S): Sperm retrieval rates. RESULT(S): Overall, 44.5% of patients with Sertoli cell only had sperm retrieved with microTESE. No difference was noted in sperm retrieval rates based on testis volume (≥15 mL vs. <15 mL, 35.3% vs. 46.1%, respectively). Patients with ≥15 mL testicular volume and FSH 10-15 mU/mL had the worst prognosis, with a sperm retrieval rate of 6.7%. CONCLUSION(S): Patients with previous testicular biopsy demonstrating Sertoli cell-only histology can be counseled that they have a reasonable likelihood of sperm retrieval with the contemporary delivery of microTESE. Given this finding, the utility of testicular biopsy before microTESE is further questioned.
OBJECTIVE: To study the outcomes of microdissection testicular sperm extraction (microTESE) among men with pure Sertoli cell-only histology on diagnostic testicular biopsy. DESIGN: Retrospective cohort study. SETTING: Tertiary referral center. PATIENT(S): Six hundred forty patients with pure Sertoli cell-only histology on testicular biopsy who underwent microTESE by a single surgeon. INTERVENTION(S): MicroTESE. MAIN OUTCOME MEASURE(S): Sperm retrieval rates. RESULT(S): Overall, 44.5% of patients with Sertoli cell only had sperm retrieved with microTESE. No difference was noted in sperm retrieval rates based on testis volume (≥15 mL vs. <15 mL, 35.3% vs. 46.1%, respectively). Patients with ≥15 mL testicular volume and FSH 10-15 mU/mL had the worst prognosis, with a sperm retrieval rate of 6.7%. CONCLUSION(S): Patients with previous testicular biopsy demonstrating Sertoli cell-only histology can be counseled that they have a reasonable likelihood of sperm retrieval with the contemporary delivery of microTESE. Given this finding, the utility of testicular biopsy before microTESE is further questioned.
Authors: F Boitrelle; G Robin; F Marcelli; M Albert; B Leroy-Martin; D Dewailly; J-M Rigot; V Mitchell Journal: Hum Reprod Date: 2011-09-18 Impact factor: 6.918
Authors: Ranjith Ramasamy; Jennifer E Reifsnyder; Campbell Bryson; Nikica Zaninovic; Deborah Liotta; Carol-Ann Cook; June Hariprashad; Dina Weiss; Queenie Neri; Gianpiero D Palermo; Peter N Schlegel Journal: Fertil Steril Date: 2011-06-12 Impact factor: 7.329
Authors: T Diesch; A Rovo; N von der Weid; M Faraci; M Pillon; A Dalissier; J-H Dalle; P Bader Journal: Bone Marrow Transplant Date: 2017-01-23 Impact factor: 5.483
Authors: Gianni Paulis; Luca Paulis; Gennaro Romano; Carmen Concas; Marika Di Sarno; Renata Pagano; Antonio Di Filippo; Maria Luisa Di Petrillo Journal: Res Rep Urol Date: 2017-10-30