Gwen L Bonner1, Andrew J Nagy2, Daniel C Jupiter3, Joaquin A Rodriguez4, Richard E Symmonds4, Robert O Carpenter4. 1. Baylor Scott & White, MS-01-712, 2401 S. 31st Street, Temple, TX 76508, USA. Electronic address: GBONNER@SW.ORG. 2. Fourth Year Medical Student, Texas A&M Health Science Center, Temple, TX, USA. 3. Department of Biostatistics, Texas A&M Health Science Center, Temple, TX, USA. 4. Minimally Invasive Surgery and Bariatric Surgery, Texas A&M Health Science Center, Temple, TX, USA.
Abstract
BACKGROUND: Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. METHODS: Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. RESULTS: There was a decrease in serum LDL-P levels, averaging 472.58 (P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. CONCLUSION: LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.
BACKGROUND: Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. METHODS: Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. RESULTS: There was a decrease in serum LDL-P levels, averaging 472.58 (P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. CONCLUSION: LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.
Authors: Beata M M Reiber; Anna-Marie R Leemeyer; Marjolein J M Bremer; Maurits de Brauw; Sjoerd C Bruin Journal: Obes Surg Date: 2021-05-08 Impact factor: 4.129