B O Estupiñán-Díaz1, L M Morales-Chacón2, I García-Maeso3, L Lorigados-Pedre4, M Báez-Martín2, M E García-Navarro5, O Trápaga-Quincoses2, N Quintanal-Cordero3, J Prince-López3, J E Bender-del Busto6. 1. Laboratorio de Anatomía Patológica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. Electronic address: baby@neuro.ciren.cu. 2. Servicio de Neurofisiología Clínica, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. 3. Servicio de Neurocirugía, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. 4. Laboratorio de Neuroinmunología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. 5. Departamento de Neuropsicología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba. 6. Servicio de Neurología, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba.
Abstract
INTRODUCTION: Corpora amylacea (CoA) are present in about 60% of atrophic hippocampi resected from patients with drug resistant temporal lobe epilepsy (DRTLE). They have also been described in the lateral temporal neocortex, although less frequently. OBJECTIVE: The objective is to measure the presence, distribution and density of CoA in the lateral temporal lobes of patients with DRTLE and focal cortical dysplasia (FCD), also examining how CoA density may be linked to demographic and clinical traits. METHODS: Resected tissue from 35 patients was analysed. CoA density was assessed with a semi-quantitative scale according to the criteria established by Cherian et al. RESULTS: Presence of CoA in the neocortex of 9 patients was associated with hippocampal sclerosis (FCD type iiia, 7 cases), disembryoplastic neuroepithelial tumour (FCD type iiib, 1 case), and cavernous angioma (FCD type iiic, 1 case). The meningeal surface (MS) was involved in all cases, and 8 cases displayed CoA in the cerebral parenchyma (white matter) and around blood vessels. CoA density on the MS showed a negative correlation with age at seizure onset (r = -0.828, P<.05) and a positive correlation with disease duration (r = 0.678, P<.05) but not with postoperative clinical outcome. CONCLUSIONS: Patients with DRTLE and a primary lesion (hippocampal sclerosis, tumour, vascular malformation) associated with mild FCD were shown to have CoA deposits in the neocortex. No association was found between presence of CoA and clinical outcome one year after surgery.
INTRODUCTION: Corpora amylacea (CoA) are present in about 60% of atrophic hippocampi resected from patients with drug resistant temporal lobe epilepsy (DRTLE). They have also been described in the lateral temporal neocortex, although less frequently. OBJECTIVE: The objective is to measure the presence, distribution and density of CoA in the lateral temporal lobes of patients with DRTLE and focal cortical dysplasia (FCD), also examining how CoA density may be linked to demographic and clinical traits. METHODS: Resected tissue from 35 patients was analysed. CoA density was assessed with a semi-quantitative scale according to the criteria established by Cherian et al. RESULTS: Presence of CoA in the neocortex of 9 patients was associated with hippocampal sclerosis (FCD type iiia, 7 cases), disembryoplastic neuroepithelial tumour (FCD type iiib, 1 case), and cavernous angioma (FCD type iiic, 1 case). The meningeal surface (MS) was involved in all cases, and 8 cases displayed CoA in the cerebral parenchyma (white matter) and around blood vessels. CoA density on the MS showed a negative correlation with age at seizure onset (r = -0.828, P<.05) and a positive correlation with disease duration (r = 0.678, P<.05) but not with postoperative clinical outcome. CONCLUSIONS:Patients with DRTLE and a primary lesion (hippocampal sclerosis, tumour, vascular malformation) associated with mild FCD were shown to have CoA deposits in the neocortex. No association was found between presence of CoA and clinical outcome one year after surgery.
Authors: Paula P Navarro; Christel Genoud; Daniel Castaño-Díez; Alexandra Graff-Meyer; Amanda J Lewis; Yvonne de Gier; Matthias E Lauer; Markus Britschgi; Bernd Bohrmann; Stephan Frank; Jürgen Hench; Gabriel Schweighauser; Annemieke J M Rozemuller; Wilma D J van de Berg; Henning Stahlberg; Sarah H Shahmoradian Journal: Sci Rep Date: 2018-12-21 Impact factor: 4.379