| Literature DB >> 25440052 |
Abstract
Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP.Entities:
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Year: 2014 PMID： 25440052 DOI： 10.1016/j.cmet.2014.10.015
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287