Literature DB >> 25440051

C16:0-ceramide signals insulin resistance.

Timothy Hla1, Richard Kolesnick2.   

Abstract

A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance (Turpin et al., 2014; Raichur et al., 2014).
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25440051      PMCID： PMC4393079          DOI： 10.1016/j.cmet.2014.10.017

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

Review 1.  Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Authors:  Alfred H Merrill
Journal:  Chem Rev       Date:  2011-09-26       Impact factor: 60.622

Review 2.  Ceramide synthases as potential targets for therapeutic intervention in human diseases.

Authors:  Joo-Won Park; Woo-Jae Park; Anthony H Futerman
Journal:  Biochim Biophys Acta       Date:  2013-09-08

Review 3.  Ceramide-rich platforms in transmembrane signaling.

Authors:  Branka Stancevic; Richard Kolesnick
Journal:  FEBS Lett       Date:  2010-02-20       Impact factor: 4.124

4.  A ceramide-centric view of insulin resistance.

Authors:  Jose A Chavez; Scott A Summers
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

5.  The metabolic syndrome.

Authors:  Robert H Eckel; K G M M Alberti; Scott M Grundy; Paul Z Zimmet
Journal:  Lancet       Date:  2010-01-16       Impact factor: 79.321

6.  Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis.

Authors:  Jerry E Chipuk; Gavin P McStay; Archana Bharti; Tomomi Kuwana; Christopher J Clarke; Leah J Siskind; Lina M Obeid; Douglas R Green
Journal:  Cell       Date:  2012-03-02       Impact factor: 41.582

7.  CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.

Authors:  Suryaprakash Raichur; Siew Tein Wang; Puck Wee Chan; Ying Li; Jianhong Ching; Bhagirath Chaurasia; Bghagirath Chaurasia; Shaillay Dogra; Miina K Öhman; Kosuke Takeda; Shigeki Sugii; Yael Pewzner-Jung; Anthony H Futerman; Scott A Summers
Journal:  Cell Metab       Date:  2014-10-07       Impact factor: 27.287

8.  Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Authors:  Sarah M Turpin; Hayley T Nicholls; Diana M Willmes; Arnaud Mourier; Susanne Brodesser; Claudia M Wunderlich; Jan Mauer; Elaine Xu; Philipp Hammerschmidt; Hella S Brönneke; Aleksandra Trifunovic; Giuseppe LoSasso; F Thomas Wunderlich; Jan-Wilhelm Kornfeld; Matthias Blüher; Martin Krönke; Jens C Brüning
Journal:  Cell Metab       Date:  2014-10-07       Impact factor: 27.287

Review 9.  Sphingolipid signaling in metabolic disorders.

Authors:  Timothy Hla; Andrew J Dannenberg
Journal:  Cell Metab       Date:  2012-09-13       Impact factor: 27.287

Review 10.  Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function.

Authors:  Svati H Shah; William E Kraus; Christopher B Newgard
Journal:  Circulation       Date:  2012-08-28       Impact factor: 29.690
  10 in total
  35 in total

1.  A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

Authors:  Min Park; Vincent Kaddai; Jianhong Ching; Kevin T Fridianto; Ryan J Sieli; Shigeki Sugii; Scott A Summers
Journal:  J Biol Chem       Date:  2016-10-04       Impact factor: 5.157

2.  Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease.

Authors:  Annelise M Poss; J Alan Maschek; James E Cox; Benedikt J Hauner; Paul N Hopkins; Steven C Hunt; William L Holland; Scott A Summers; Mary C Playdon
Journal:  J Clin Invest       Date:  2020-03-02       Impact factor: 14.808

3.  Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

Authors:  B Lee Peterlin; Michelle M Mielke; Alex M Dickens; Subroto Chatterjee; Paul Dash; Guillermo Alexander; Rebeca V A Vieira; Veera Venkata Ratnam Bandaru; Joelle M Dorskind; Gretchen E Tietjen; Norman H Haughey
Journal:  Neurology       Date:  2015-09-09       Impact factor: 9.910

4.  Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.

Authors:  Natalia Santos Ferreira; Hanne Engelsby; Ditte Neess; Samuel L Kelly; Giora Volpert; Alfred H Merrill; Anthony H Futerman; Nils J Færgeman
Journal:  J Biol Chem       Date:  2017-03-19       Impact factor: 5.157

Review 5.  Sphingolipids and phospholipids in insulin resistance and related metabolic disorders.

Authors:  Peter J Meikle; Scott A Summers
Journal:  Nat Rev Endocrinol       Date:  2016-10-21       Impact factor: 43.330

6.  Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge.

Authors:  Elizabeth S Moore; Erin K Daugherity; David I Karambizi; Bethany P Cummings; Erica Behling-Kelly; Deanna M W Schaefer; Teresa L Southard; Joseph W McFadden; Robert S Weiss
Journal:  J Biol Chem       Date:  2019-08-21       Impact factor: 5.157

7.  The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication.

Authors:  Carlos H Sponton; Takashi Hosono; Junki Taura; Mark P Jedrychowski; Takeshi Yoneshiro; Qiang Wang; Makoto Takahashi; Yumi Matsui; Kenji Ikeda; Yasuo Oguri; Kazuki Tajima; Kosaku Shinoda; Rachana N Pradhan; Yong Chen; Zachary Brown; Lindsay S Roberts; Carl C Ward; Hiroki Taoka; Yoko Yokoyama; Mitsuhiro Watanabe; Hiroshi Karasawa; Daniel K Nomura; Shingo Kajimura
Journal:  EMBO Rep       Date:  2020-07-16       Impact factor: 8.807

8.  Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Authors:  Leigh Goedeke; Jamie Bates; Daniel F Vatner; Rachel J Perry; Ting Wang; Ricardo Ramirez; Li Li; Matthew W Ellis; Dongyan Zhang; Kari E Wong; Carine Beysen; Gary W Cline; Adrian S Ray; Gerald I Shulman
Journal:  Hepatology       Date:  2018-12       Impact factor: 17.425

Review 9.  Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.

Authors:  Max C Petersen; Gerald I Shulman
Journal:  Trends Pharmacol Sci       Date:  2017-05-24       Impact factor: 14.819

10.  A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells.

Authors:  Andrew K Rudd; Neel Mittal; Esther W Lim; Christian M Metallo; Neal K Devaraj
Journal:  J Am Chem Soc       Date:  2020-10-12       Impact factor: 15.419
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