Fu-Hsiung Su1, Shih-Ni Chang2, Fung-Chang Sung3, Chien-Tien Su4, Ying-Hua Shieh5, Cheng-Chieh Lin6, Chih-Ching Yeh7. 1. Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan. 2. PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Management Office for Health Data, China Medical University, Taichung, Taiwan. 3. Management Office for Health Data, China Medical University, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan. 4. Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. 5. Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 6. Division of Family Medicine, China Medical University, Taichung, Taiwan. 7. Department of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. Electronic address: ccyeh@tmu.edu.tw.
Abstract
OBJECTIVE: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. DESIGN: A nationwide, population-based cohort study. SETTING: Not applicable. PATIENT(S): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. RESULT(S): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. CONCLUSION(S): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
OBJECTIVE: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. DESIGN: A nationwide, population-based cohort study. SETTING: Not applicable. PATIENT(S): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. RESULT(S): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. CONCLUSION(S): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
Authors: Paul Wasuwanich; Catherine W Striley; Saleem Kamili; Eyasu H Teshale; Eric C Seaberg; Wikrom Karnsakul Journal: J Viral Hepat Date: 2022-02-02 Impact factor: 3.517
Authors: Thiago A Teixeira; Yasmin C Oliveira; Felipe S Bernardes; Esper G Kallas; Amaro N Duarte-Neto; Sandro C Esteves; Joël R Drevet; Jorge Hallak Journal: Asian J Androl Date: 2021 Jul-Aug Impact factor: 3.285