David Llaneza-Suarez1, Placido Llaneza2, Celestino González3, Pedro De-La-Fuente3, Carlos García-Ochoa4, Pablo Garrido3, Vanesa Castañón2, Faustino R Pérez-López5. 1. Department of Obstetrics and Gynecology, University Central Hospital of Asturias, University of Oviedo, Oviedo, Spain; Asturias In Vitro Fertilization Center (CEFIVA), Oviedo, Spain. Electronic address: llaneza@uniovi.es. 2. Department of Obstetrics and Gynecology, University Central Hospital of Asturias, University of Oviedo, Oviedo, Spain. 3. Department of Physiology, University of Oviedo, Oviedo, Spain. 4. Asturias In Vitro Fertilization Center (CEFIVA), Oviedo, Spain. 5. Department of Obstetrics and Gynecology, "Lozano Blesa" University Hospital, University of Zaragoza, Zaragoza, Spain.
Abstract
OBJECTIVE: To analyze follicular fluid leptin (FFL) levels, abdominal obesity, and insulin resistance as predictors of in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) outcome. DESIGN: Observational study. SETTING: Academic medical center. PATIENT(S): A sample of 130 infertile women aged 26-40 years without polycystic ovary syndrome. INTERVENTION(S): Measurement of FFL levels in controlled ovarian hyperstimulation cycles with an antagonist and agonist protocol for IVF-ICSI. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): Mean FFL values were significantly higher in pregnancies not ending in a live birth, even after adjustment for waist circumference and insulin resistance. A multivariable model obtained with the use of logistic binary regression analysis showed that waist circumference and insulin resistance had no influence over IVF-ICSI outcomes, but a higher number of follicles, lower serum progesterone levels on the day before α-hCG administration, and lower FFL concentrations were significantly associated with a higher probability of having a live birth. The multivariate model reached a sensitivity of 87% and a specificity of 71% for predicting the possibility of pregnancy ending in a live birth. CONCLUSION(S): High FFL levels were associated with abdominal obesity, insulin resistance, and a lower live birth rate after IVF-ICSI. Further investigations are warranted to define the precise roles of leptin, obesity, and insulin resistance on IVF-ICSI outcomes.
OBJECTIVE: To analyze follicular fluid leptin (FFL) levels, abdominal obesity, and insulin resistance as predictors of in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) outcome. DESIGN: Observational study. SETTING: Academic medical center. PATIENT(S): A sample of 130 infertile women aged 26-40 years without polycystic ovary syndrome. INTERVENTION(S): Measurement of FFL levels in controlled ovarian hyperstimulation cycles with an antagonist and agonist protocol for IVF-ICSI. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): Mean FFL values were significantly higher in pregnancies not ending in a live birth, even after adjustment for waist circumference and insulin resistance. A multivariable model obtained with the use of logistic binary regression analysis showed that waist circumference and insulin resistance had no influence over IVF-ICSI outcomes, but a higher number of follicles, lower serum progesterone levels on the day before α-hCG administration, and lower FFL concentrations were significantly associated with a higher probability of having a live birth. The multivariate model reached a sensitivity of 87% and a specificity of 71% for predicting the possibility of pregnancy ending in a live birth. CONCLUSION(S): High FFL levels were associated with abdominal obesity, insulin resistance, and a lower live birth rate after IVF-ICSI. Further investigations are warranted to define the precise roles of leptin, obesity, and insulin resistance on IVF-ICSI outcomes.
Authors: Henrik Svensson; Snorri Einarsson; Daniel Olausson; Linda Kluge; Christina Bergh; Staffan Edén; Malin Lönn; Ann Thurin-Kjellberg Journal: Sci Rep Date: 2022-08-03 Impact factor: 4.996
Authors: Jordan H Machlin; Seth J Barishansky; John Kelsh; Megan J Larmore; Brian W Johnson; Michele T Pritchard; Mary Ellen Pavone; Francesca E Duncan Journal: Int J Mol Sci Date: 2021-05-05 Impact factor: 5.923
Authors: Torie C Plowden; Shvetha M Zarek; Elizabeth A DeVilbiss; Jeannie G Radoc; Keewan Kim; Lindsey A Sjaarda; Enrique F Schisterman; Robert M Silver; Daniel L Kuhr; Ukpebo R Omosigho; Edwina H Yeung; Sunni L Mumford Journal: J Endocr Soc Date: 2019-08-21