Nicolette E Deveneau1, Omar Sinno2, Miriam Krause3, Daniel Eastwood4, Jay I Sandlow5, Paul Robb2, Amy Granlund2, Estil Y Strawn2. 1. Department of Obstetrics and Gynecology, Froedtert Medical College Lab Building, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: ndeveneau@gmail.com. 2. Department of Obstetrics and Gynecology, Froedtert Medical College Lab Building, Medical College of Wisconsin, Milwaukee, Wisconsin. 3. Department of Urology, Froedtert Medical College Lab Building, Medical College of Wisconsin, Milwaukee, Wisconsin. 4. Division of Biostatistics, Medical College of Wisconsin, Biostatistics Consulting Service, Milwaukee, Wisconsin. 5. Department of Obstetrics, Gynecology and Women's Health, University of Louisville, School of Medicine, Louisville, Kentucky.
Abstract
OBJECTIVE: To determine whether there is a difference in ongoing pregnancy rates (PRs) between patients undergoing IUI with strict sperm morphology ≤4% compared with >4% on initial semen analysis. DESIGN: Retrospective chart review with multivariate analysis. SETTING: Academic outpatient reproductive center. PATIENT(S): A total of 408 couples with male and/or female factor infertility and known strict sperm morphology (SSM). INTERVENTION(S): A total of 856 IUIs with partner's sperm (IUI-P). MAIN OUTCOME MEASURE(S): Ongoing PRs based on ultrasound documentation of intrauterine pregnancy with fetal heart tones. RESULT(S): There is no statistically significant difference in per cycle PRs when comparing patients with a strict sperm morphology of ≤4% versus >4% who undergo IUI-P (17.3% vs. 16.7%; odds ratio 0.954, 95% confidence interval 0.66-1.37). Multiple potential confounding factors were assessed using multivariate analysis. CONCLUSION(S): Strict sperm morphology ≤4% is not associated with lower PRs in couples undergoing IUI-P, and thus should not be the sole reason for advancing to IVF.
OBJECTIVE: To determine whether there is a difference in ongoing pregnancy rates (PRs) between patients undergoing IUI with strict sperm morphology ≤4% compared with >4% on initial semen analysis. DESIGN: Retrospective chart review with multivariate analysis. SETTING: Academic outpatient reproductive center. PATIENT(S): A total of 408 couples with male and/or female factor infertility and known strict sperm morphology (SSM). INTERVENTION(S): A total of 856 IUIs with partner's sperm (IUI-P). MAIN OUTCOME MEASURE(S): Ongoing PRs based on ultrasound documentation of intrauterine pregnancy with fetal heart tones. RESULT(S): There is no statistically significant difference in per cycle PRs when comparing patients with a strict sperm morphology of ≤4% versus >4% who undergo IUI-P (17.3% vs. 16.7%; odds ratio 0.954, 95% confidence interval 0.66-1.37). Multiple potential confounding factors were assessed using multivariate analysis. CONCLUSION(S): Strict sperm morphology ≤4% is not associated with lower PRs in couples undergoing IUI-P, and thus should not be the sole reason for advancing to IVF.
Authors: Patrícia de Moraes De Zorzi; Ana Paula de Souza Kussler; Anita Mylius Pimentel; Edison Capp; Helena von Eye Corleta Journal: JBRA Assist Reprod Date: 2022-04-17
Authors: Jamie Stanhiser; Jennifer E Mersereau; Daquan Dock; Caitlin Boylan; Hunter Caprell; R Matthew Coward; Dara S Berger; Marc Fritz Journal: F S Rep Date: 2020-12-09