Literature DB >> 25439168

Production of (211)At by a vertical beam irradiation method.

Kotaro Nagatsu1, Katsuyuki Minegishi2, Masami Fukada2, Hisashi Suzuki2, Sumitaka Hasegawa2, Ming-Rong Zhang2.   

Abstract

We produced (211)At by irradiating the semi-sealed encapsulated Bi target with an external vertical beam. At 28.5MeV, the yield of (211)At was 22MBq/μAh (600μCi/μAh). (211)At was recovered by dry distillation, and 80% of the produced (211)At was successfully obtained in dry Na(211)At form within 2h from the end of bombardment (EOB). The radionuclidic purity of (211)At was >99% at 5h from EOB.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords:  (211)At production; Dry distillation; Encapsulated target; Vertical irradiation

Mesh：

Substances：

Year:  2014        PMID： 25439168     DOI： 10.1016/j.apradiso.2014.09.012

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  11 in total

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Journal:  Target Oncol       Date:  2018-04       Impact factor: 4.493

2.  Utility of 211At-Trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically Relevant Mouse Model.

Authors:  Huizi Keiko Li; Yukie Morokoshi; Satoshi Kodaira; Tamon Kusumoto; Katsuyuki Minegishi; Hiroaki Kanda; Kotaro Nagatsu; Sumitaka Hasegawa
Journal:  J Nucl Med       Date:  2021-02-05       Impact factor: 10.057

3.  Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors.

Authors:  Satoshi Kodaira; Huizi Keiko Li; Teruaki Konishi; Hisashi Kitamura; Mieko Kurano; Sumitaka Hasegawa
Journal:  PLoS One       Date:  2017-06-28       Impact factor: 3.240

4.  Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model.

Authors:  Yasuhiro Ohshima; Hitomi Sudo; Shigeki Watanabe; Kotaro Nagatsu; Atsushi B Tsuji; Tetsuya Sakashita; Yoichi M Ito; Keiichiro Yoshinaga; Tatsuya Higashi; Noriko S Ishioka
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-01-19       Impact factor: 9.236

Review 5.  Realizing Clinical Trials with Astatine-211: The Chemistry Infrastructure.

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6.  α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.

Authors:  Huizi Keiko Li; Aya Sugyo; Atsushi B Tsuji; Yukie Morokoshi; Katsuyuki Minegishi; Kotaro Nagatsu; Hiroaki Kanda; Yosuke Harada; Satoshi Nagayama; Toyomasa Katagiri; Yusuke Nakamura; Tatsuya Higashi; Sumitaka Hasegawa
Journal:  Cancer Sci       Date:  2018-06-27       Impact factor: 6.716

7.  Preclinical Evaluation of the Acute Radiotoxicity of the α-Emitting Molecular-Targeted Therapeutic Agent 211At-MABG for the Treatment of Malignant Pheochromocytoma in Normal Mice.

Authors:  Hitomi Sudo; Atsushi B Tsuji; Aya Sugyo; Kotaro Nagatsu; Katsuyuki Minegishi; Noriko S Ishioka; Hiroshi Ito; Keiichiro Yoshinaga; Tatsuya Higashi
Journal:  Transl Oncol       Date:  2019-05-09       Impact factor: 4.243

8.  Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution.

Authors:  Yoshifumi Shirakami; Tadashi Watabe; Honoka Obata; Kazuko Kaneda; Kazuhiro Ooe; Yuwei Liu; Takahiro Teramoto; Atsushi Toyoshima; Atsushi Shinohara; Eku Shimosegawa; Jun Hatazawa; Koichi Fukase
Journal:  Sci Rep       Date:  2021-06-21       Impact factor: 4.379

Review 9.  Production, purification and availability of 211At: Near term steps towards global access.

Authors:  Yutian Feng; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2021-06-10       Impact factor: 2.947

10.  Locoregional therapy with α-emitting trastuzumab against peritoneal metastasis of human epidermal growth factor receptor 2-positive gastric cancer in mice.

Authors:  Huizi Keiko Li; Yukie Morokoshi; Kotaro Nagatsu; Tadashi Kamada; Sumitaka Hasegawa
Journal:  Cancer Sci       Date:  2017-06-27       Impact factor: 6.716
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