Literature DB >> 25438492

Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine.

S R Mittal.   

Abstract

A case of unstable angina developed slow junctional rhythm with QTc prolongation and transient Torsades de pointes following simultaneous use of Ivabradine, Diltiazem and Ranolazine. Effect of Diltiazem on hepatic isoenzyme CYP 3A could be responsible. Such a combination should be avoided.

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Year:  2014        PMID： 25438492

Source DB:  PubMed          Journal:  J Assoc Physicians India        ISSN： 0004-5772


  7 in total

Review 1.  Reckless administration of QT interval-prolonging agents in elderly patients with drug-induced torsade de pointes.

Authors:  Galia Jackobson; Narin Nard Carmel; Dor Lotan; Anjelika Kremer; Dan Justo
Journal:  Z Gerontol Geriatr       Date:  2016-11-22       Impact factor: 1.281

2.  Acute on Chronic Ivabradine Overdose: a Case Report.

Authors:  Kevin Maskell; Adele Tse; Carl E Wolf; Michelle Troendle
Journal:  J Med Toxicol       Date:  2016-02-08

Review 3.  Heart rate reduction in coronary artery disease and heart failure.

Authors:  Roberto Ferrari; Kim Fox
Journal:  Nat Rev Cardiol       Date:  2016-05-26       Impact factor: 32.419

4.  hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.

Authors:  Jules C Hancox; Dario Melgari; Christopher E Dempsey; Kieran E Brack; John Mitcheson; G André Ng
Journal:  Ther Adv Drug Saf       Date:  2015-08

Review 5.  The Role of Ivabradine in the Management of Angina Pectoris.

Authors:  Alessandra Giavarini; Ranil de Silva
Journal:  Cardiovasc Drugs Ther       Date:  2016-08       Impact factor: 3.727

6.  hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.

Authors:  Dario Melgari; Kieran E Brack; Chuan Zhang; Yihong Zhang; Aziza El Harchi; John S Mitcheson; Christopher E Dempsey; G André Ng; Jules C Hancox
Journal:  J Am Heart Assoc       Date:  2015-04-24       Impact factor: 5.501

7.  Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator.

Authors:  Beth McMillan; David J Gavaghan; Gary R Mirams
Journal:  Toxicol Res (Camb)       Date:  2017-09-14       Impact factor: 3.524
  7 in total

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