Literature DB >> 25438366

Epigenetics: modifying the genetic blueprint.

Joel C Eissenberg.   

Abstract

The sequence of the human genome represents our genetic blueprint. While it is now possible to draw direct connections between specific DNA sequences and specific physical features and to predict disease risk, the effects of certain genes can be masked by a process called "epigenetics." Here, I summarize our current understanding of epigenetics and it affects gene expression, with impacts on health and aging.

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Year:  2014        PMID： 25438366      PMCID： PMC6172102     

Source DB:  PubMed          Journal:  Mo Med        ISSN： 0026-6620


  14 in total

1.  Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins.

Authors:  A J MacGregor; H Snieder; A S Rigby; M Koskenvuo; J Kaprio; K Aho; A J Silman
Journal:  Arthritis Rheum       Date:  2000-01

2.  Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

Authors:  G P Pfeifer; S D Steigerwald; R S Hansen; S M Gartler; A D Riggs
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

3.  Epigenetics as a unifying principle in the aetiology of complex traits and diseases.

Authors:  Arturas Petronis
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

4.  Epigenetic differences arise during the lifetime of monozygotic twins.

Authors:  Mario F Fraga; Esteban Ballestar; Maria F Paz; Santiago Ropero; Fernando Setien; Maria L Ballestar; Damia Heine-Suñer; Juan C Cigudosa; Miguel Urioste; Javier Benitez; Manuel Boix-Chornet; Abel Sanchez-Aguilera; Charlotte Ling; Emma Carlsson; Pernille Poulsen; Allan Vaag; Zarko Stephan; Tim D Spector; Yue-Zhong Wu; Christoph Plass; Manel Esteller
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-11       Impact factor: 11.205

5.  A population-based twin study of lifetime major depression in men and women.

Authors:  K S Kendler; C A Prescott
Journal:  Arch Gen Psychiatry       Date:  1999-01

6.  A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns.

Authors:  Diane P Genereux; Brooks E Miner; Carl T Bergstrom; Charles D Laird
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-12       Impact factor: 11.205

7.  Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse.

Authors:  K Swisshelm; C M Disteche; J Thorvaldsen; A Nelson; D Salk
Journal:  Mutat Res       Date:  1990 May-Jul       Impact factor: 2.433

Review 8.  Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.

Authors:  T T Yen; A M Gill; L G Frigeri; G S Barsh; G L Wolff
Journal:  FASEB J       Date:  1994-05       Impact factor: 5.191

9.  Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins.

Authors:  A J Silman; J Newman; A J MacGregor
Journal:  Arthritis Rheum       Date:  1996-05

Review 10.  Genetics and epigenetics of aging and longevity.

Authors:  Alexey A Moskalev; Alexander M Aliper; Zeljka Smit-McBride; Anton Buzdin; Alex Zhavoronkov
Journal:  Cell Cycle       Date:  2014-03-06       Impact factor: 4.534
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  1 in total

1.  News from the NIH: potential contributions of the behavioral and social sciences to the precision medicine initiative.

Authors:  William T Riley; Wendy J Nilsen; Teri A Manolio; Daniel R Masys; Michael Lauer
Journal:  Transl Behav Med       Date:  2015-09       Impact factor: 3.046
  1 in total

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