Lindsay D Oliver1, Derek G V Mitchell2, Isabel Dziobek3, Julia MacKinley4, Kristy Coleman4, Katherine P Rankin5, Elizabeth C Finger6. 1. Schulich School of Medicine & Dentistry, Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada. 2. Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada; Schulich School of Medicine & Dentistry, Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada. 3. Cluster of Excellence Languages of Emotion, Freie Universität Berlin, Berlin, Germany. 4. Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada. 5. Department of Neurology, University of California San Francisco School of Medicine, San Francisco, California, USA. 6. Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada; Schulich School of Medicine & Dentistry, Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada. Electronic address: Elizabeth.Finger@lhsc.on.ca.
Abstract
OBJECTIVES: Behavioural variant frontotemporal dementia (bvFTD) is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe atrophy primarily affecting social cognition and emotion, including loss of empathy. Many consider empathy to be a multidimensional construct, including cognitive empathy (the ability to adopt and understand another's perspective) and emotional empathy (the capacity to share another's emotional experience). Cognitive and emotional empathy deficits have been associated with bvFTD; however, little is known regarding the performance of patients with bvFTD on behavioural measures of emotional empathy, and whether empathic responses differ for negative versus positive stimuli. METHODS: 24 patients with bvFTD and 24 healthy controls completed the Multifaceted Empathy Test (MET; Dziobek et al., 2008), a performance-based task that taps both cognitive and emotional facets of empathy, and allows for the discrimination of responses to negative versus positive realistic images. MET scores were also compared with caregiver ratings of patient behaviour on the Interpersonal Reactivity Index, which assesses patients' everyday demonstrations of perspective taking and empathic concern. RESULTS: Patients with bvFTD were less accurate than controls at inferring mental states for negative and positive stimuli. They also demonstrated lower levels of shared emotional experience, more positive emotional reactions, and diminished arousal to negative social stimuli relative to controls. Patients showed reduced emotional reactions to negative non-social stimuli as well. Lastly, the MET and IRI measures of emotional empathy were found to be significantly correlated within the bvFTD group. CONCLUSIONS: The results suggest that patients with bvFTD show a global deficit in cognitive empathy, and deficient emotional empathy for negative, but not positive, experiences. Further, a generalized emotional processing impairment for negative stimuli was observed, which could contribute to the emotional empathy deficit. This work highlights potential treatment targets and a means to assess the impact of novel therapies on socioemotional impairment in bvFTD.
OBJECTIVES: Behavioural variant frontotemporal dementia (bvFTD) is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe atrophy primarily affecting social cognition and emotion, including loss of empathy. Many consider empathy to be a multidimensional construct, including cognitive empathy (the ability to adopt and understand another's perspective) and emotional empathy (the capacity to share another's emotional experience). Cognitive and emotional empathy deficits have been associated with bvFTD; however, little is known regarding the performance of patients with bvFTD on behavioural measures of emotional empathy, and whether empathic responses differ for negative versus positive stimuli. METHODS: 24 patients with bvFTD and 24 healthy controls completed the Multifaceted Empathy Test (MET; Dziobek et al., 2008), a performance-based task that taps both cognitive and emotional facets of empathy, and allows for the discrimination of responses to negative versus positive realistic images. MET scores were also compared with caregiver ratings of patient behaviour on the Interpersonal Reactivity Index, which assesses patients' everyday demonstrations of perspective taking and empathic concern. RESULTS:Patients with bvFTD were less accurate than controls at inferring mental states for negative and positive stimuli. They also demonstrated lower levels of shared emotional experience, more positive emotional reactions, and diminished arousal to negative social stimuli relative to controls. Patients showed reduced emotional reactions to negative non-social stimuli as well. Lastly, the MET and IRI measures of emotional empathy were found to be significantly correlated within the bvFTD group. CONCLUSIONS: The results suggest that patients with bvFTD show a global deficit in cognitive empathy, and deficient emotional empathy for negative, but not positive, experiences. Further, a generalized emotional processing impairment for negative stimuli was observed, which could contribute to the emotional empathy deficit. This work highlights potential treatment targets and a means to assess the impact of novel therapies on socioemotional impairment in bvFTD.
Authors: Sylvia S Fong; Carlos David Navarrete; Sean E Perfecto; Andrew R Carr; Elvira E Jimenez; Mario F Mendez Journal: Soc Neurosci Date: 2016-05-23 Impact factor: 2.083
Authors: Lindsay D Oliver; Joana B Vieira; Richard W J Neufeld; Isabel Dziobek; Derek G V Mitchell Journal: Soc Cogn Affect Neurosci Date: 2018-04-01 Impact factor: 3.436
Authors: Casey L Brown; Alice Y Hua; Lize De Coster; Virginia E Sturm; Joel H Kramer; Howard J Rosen; Bruce L Miller; Robert W Levenson Journal: Soc Cogn Affect Neurosci Date: 2020-07-01 Impact factor: 3.436
Authors: Miriam H Cohen; Amelia M Carton; Christopher J Hardy; Hannah L Golden; Camilla N Clark; Phillip D Fletcher; Kankamol Jaisin; Charles R Marshall; Susie M D Henley; Jonathan D Rohrer; Sebastian J Crutch; Jason D Warren Journal: Neuropsychologia Date: 2015-12-31 Impact factor: 3.139