AIM: The bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients. MATERIALS & METHODS: Sputum specimens were investigated using culture and PCR, serological status evaluation was performed and the inflammatory profile was associated with the microbiological results. RESULTS & CONCLUSION: The majority of the patients (65.2%) had very severe airway obstruction. The most common bacteria were Haemophilus influenzae and Pseudomonas aeruginosa (23.9 and 14.1%, respectively). Acinetobacter baumannii- and P. aeruginosa-positive cultures were associated with prolonged hospitalization and severe airway obstruction (p = 0.03 and 0.031, respectively). Chlamydia pneumoniae or Mycoplasma pneumoniae infection was diagnosed in four and two patients, respectively. Discrepant results were detected between PCR and serology, especially regarding C. pneumoniae.
AIM: The bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients. MATERIALS & METHODS: Sputum specimens were investigated using culture and PCR, serological status evaluation was performed and the inflammatory profile was associated with the microbiological results. RESULTS & CONCLUSION: The majority of the patients (65.2%) had very severe airway obstruction. The most common bacteria were Haemophilus influenzae and Pseudomonas aeruginosa (23.9 and 14.1%, respectively). Acinetobacter baumannii- and P. aeruginosa-positive cultures were associated with prolonged hospitalization and severe airway obstruction (p = 0.03 and 0.031, respectively). Chlamydia pneumoniae or Mycoplasma pneumoniae infection was diagnosed in four and two patients, respectively. Discrepant results were detected between PCR and serology, especially regarding C. pneumoniae.
Authors: Marc A Sze; Pedro A Dimitriu; Masaru Suzuki; John E McDonough; Josh D Campbell; John F Brothers; John R Erb-Downward; Gary B Huffnagle; Shizu Hayashi; W Mark Elliott; Joel Cooper; Don D Sin; Marc E Lenburg; Avrum Spira; William W Mohn; James C Hogg Journal: Am J Respir Crit Care Med Date: 2015-08-15 Impact factor: 21.405
Authors: Chi Young Jung; Yeoung Hun Choe; Sang Yeub Lee; Woo Jin Kim; Jong Deog Lee; Seung Won Ra; Eu Gene Choi; Jae Seung Lee; Myung Jae Park; Ju Ock Na Journal: Korean J Intern Med Date: 2018-06-25 Impact factor: 2.884