Literature DB >> 25436989

Bacterial histidine kinases as novel antibacterial drug targets.

Agnieszka E Bem1, Nadya Velikova, M Teresa Pellicer, Peter van Baarlen, Alberto Marina, Jerry M Wells.   

Abstract

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.

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Year:  2014        PMID： 25436989     DOI： 10.1021/cb5007135

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  59 in total

1.  Polymorphisms in Regulator of Cov Contribute to the Molecular Pathogenesis of Serotype M28 Group A Streptococcus.

Authors:  Paul E Bernard; Priyanka Kachroo; Jesus M Eraso; Luchang Zhu; Jessica E Madry; Sarah E Linson; Matthew Ojeda Saavedra; Concepcion Cantu; James M Musser; Randall J Olsen
Journal:  Am J Pathol       Date:  2019-07-29       Impact factor: 4.307

Review 2.  Roles of two-component regulatory systems in antibiotic resistance.

Authors:  Aimee Rp Tierney; Philip N Rather
Journal:  Future Microbiol       Date:  2019-05-08       Impact factor: 3.165

3.  Exploration of the Effects of γ-Phosphate-Modified ATP Analogues on Histidine Kinase Autophosphorylation.

Authors:  Olivia M Chase; Adeline Espinasse; Kaelyn E Wilke; Erin E Carlson
Journal:  Biochemistry       Date:  2018-07-11       Impact factor: 3.162

4.  Systematic Analysis of Two-Component Systems in Citrobacter rodentium Reveals Positive and Negative Roles in Virulence.

Authors:  Jenny-Lee Thomassin; Jean-Mathieu Leclerc; Natalia Giannakopoulou; Lei Zhu; Kristiana Salmon; Andrea Portt; France Daigle; Hervé Le Moual; Samantha Gruenheid
Journal:  Infect Immun       Date:  2017-01-26       Impact factor: 3.441

5.  Regulatory Role of an Interdomain Linker in the Bacterial Chemotaxis Histidine Kinase CheA.

Authors:  Xueye Ding; Qiang He; Fenglin Shen; Frederick W Dahlquist; Xiqing Wang
Journal:  J Bacteriol       Date:  2018-04-24       Impact factor: 3.490

Review 6.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

Review 7.  Synthesis of histidine kinase inhibitors and their biological properties.

Authors:  Miyanou Rosales-Hurtado; Patrick Meffre; Hendrik Szurmant; Zohra Benfodda
Journal:  Med Res Rev       Date:  2019-12-05       Impact factor: 12.944

8.  Screening serine/threonine and tyrosine kinase inhibitors for histidine kinase inhibition.

Authors:  Kaelyn E Wilke; Conrad A Fihn; Erin E Carlson
Journal:  Bioorg Med Chem       Date:  2018-04-22       Impact factor: 3.641

9.  Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.

Authors:  Manibarsha Goswami; Kaelyn E Wilke; Erin E Carlson
Journal:  J Med Chem       Date:  2017-10-03       Impact factor: 7.446

10.  The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.

Authors:  Thibaut Boibessot; Christopher P Zschiedrich; Alexandre Lebeau; David Bénimèlis; Catherine Dunyach-Rémy; Jean-Philippe Lavigne; Hendrik Szurmant; Zohra Benfodda; Patrick Meffre
Journal:  J Med Chem       Date:  2016-09-26       Impact factor: 7.446
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