| Literature DB >> 25436422 |
Yu Zhang1, Cheng Ge1, Lin Wang1, Xinxin Liu1, Yifei Chen1, Mengmeng Li1, Mei Zhang2.
Abstract
Dickkopf1 (DKK1), a canonical Wnt/β-catenin pathway antagonist, is closely associated with cardiovascular disease and adipogenesis. We performed an in vitro study to determine whether oxidized low-density lipoprotein (ox-LDL) increased the expression of DKK1 in macrophages and whether β-catenin and liver X receptor α (LXRα) were involved in this regulation. Induction of DKK1 expression by ox-LDL decreased the level of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) via a Wnt/β-catenin pathway and increased ATP-binding cassette transporter A/G1 (ABCA/G1) levels via a signal transducer and activator of transcription 3 (STAT3) pathway. Lower LOX-1 and higher ABCA/G1 levels inhibited cholesterol loading in macrophages. In conclusion, ox-LDL may induce DKK1 expression in macrophages to inhibit the accumulation of lipids through a mechanism that involves downregulation of LOX-1-mediated lipid uptake and upregulation of ABCA/G1-dependent cholesterol efflux.Entities:
Keywords: ATP-binding cassette transporter A/G1; Dickkopf1; Lectin-like oxidized low-density lipoprotein receptor-1; Lipid metabolism
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Year: 2014 PMID： 25436422 DOI： 10.1016/j.febslet.2014.11.023
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124