UNLABELLED: Clinical characteristics corroborated by laboratory investigations are essential to determine the etiology in cases of childhood neutropenia and the level of future health-care needs. Here the presentation, findings, and need of interventions in different types of neutropenia in children followed at our center from 2007 to 2012 were investigated retrospectively. Children with congenital and autoimmune neutropenia presented at a significantly younger age and with lower absolute neutrophil granulocyte counts than those with other types of neutropenia (p < 0.01-0.05). The duration of neutropenia, in case of remission, was shorter in post-infection and drug-induced cases compared to autoimmune and chronic idiopathic neutropenias (p = 0.001). Least affected from infections were children with ethnic and post-infection neutropenias compared to the others (p = 0.01-0.05). With the exception of congenital and autoimmune neutropenias, neutropenic children had few clinical infections and few hospital admissions even though the outpatient visit frequency was similar among the groups. A vast majority of the patients received no antibiotic prophylaxis. CONCLUSION: The majority of patients with pediatric neutropenia, apart from congenital types, display a benign clinical course. Our data suggest that most neutropenic children need neither antibiotic prophylaxis nor extensive medical attention.
UNLABELLED: Clinical characteristics corroborated by laboratory investigations are essential to determine the etiology in cases of childhood neutropenia and the level of future health-care needs. Here the presentation, findings, and need of interventions in different types of neutropenia in children followed at our center from 2007 to 2012 were investigated retrospectively. Children with congenital and autoimmune neutropenia presented at a significantly younger age and with lower absolute neutrophil granulocyte counts than those with other types of neutropenia (p < 0.01-0.05). The duration of neutropenia, in case of remission, was shorter in post-infection and drug-induced cases compared to autoimmune and chronic idiopathic neutropenias (p = 0.001). Least affected from infections were children with ethnic and post-infection neutropenias compared to the others (p = 0.01-0.05). With the exception of congenital and autoimmune neutropenias, neutropenicchildren had few clinical infections and few hospital admissions even though the outpatient visit frequency was similar among the groups. A vast majority of the patients received no antibiotic prophylaxis. CONCLUSION: The majority of patients with pediatric neutropenia, apart from congenital types, display a benign clinical course. Our data suggest that most neutropenicchildren need neither antibiotic prophylaxis nor extensive medical attention.
Authors: David R Crosslin; Andrew McDavid; Noah Weston; Sarah C Nelson; Xiuwen Zheng; Eugene Hart; Mariza de Andrade; Iftikhar J Kullo; Catherine A McCarty; Kimberly F Doheny; Elizabeth Pugh; Abel Kho; M Geoffrey Hayes; Stephanie Pretel; Alexander Saip; Marylyn D Ritchie; Dana C Crawford; Paul K Crane; Katherine Newton; Rongling Li; Daniel B Mirel; Andrew Crenshaw; Eric B Larson; Chris S Carlson; Gail P Jarvik Journal: Hum Genet Date: 2011-10-30 Impact factor: 4.132
Authors: Kyriaki Karavanaki; Sophia Polychronopoulou; Maria Giannaki; Fotis Haliotis; Bettiina Sider; Maria Brisimitzi; C Dimitriou; G Scordias; F Marangou; A Stamatiadou; S Avlonitis Journal: Acta Paediatr Date: 2006-05 Impact factor: 2.299