Jure Peklar1, Aisling M O'Halloran2, Ian D Maidment3, Martin C Henman2, Rose Anne Kenny4, Mitja Kos5. 1. Faculty for Pharmacy, University of Ljubljana, Ljubljana, Slovenia; School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland. Electronic address: peklarj@tcd.ie. 2. The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, Ireland. 3. Pharmacy, School of Life and Health Sciences, Aston University, Birmingham, UK; Medicines and Devices in Ageing Cluster, Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham, UK. 4. The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, Ireland; Department of Medical Gerontology, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, St James's Hospital, Dublin, Ireland. 5. Faculty for Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Abstract
OBJECTIVE: To explore the association between use of sedative drugs and frailty. DESIGN: Cross-sectional study. SETTING: First wave of The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort of the community-dwelling population aged 50 years or older in Ireland. PARTICIPANTS: Participants were 1642 men and 1804 women aged 65 years or older. MEASUREMENTS: Regular use of sedative drugs determined according to the sedative load (SL) model, frailty phenotype status, and frailty deficit index (FI) score assessed using validated, established protocols. RESULTS: Overall, 19% of the participants took sedative drugs, most frequently hypnotics and antidepressants. Sedative drug use was at 46% for frail, 23% for prefrail, and 9% for nonfrail participants. After adjustment for covariates, SL was positively associated with being prefrail (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.11-1.46) and frail (OR 1.30; 95% CI 1.02-1.64). Advancing age but not sex remained significant (P < .001). After adjustment for covariates, the association between SL and the FI was also significant at P ≤ .001 (β = 1.77; 95% CI 1.13-2.42). CONCLUSION: Higher SL was positively associated with phenotype frailty and the FI. This suggests that careful consideration must be given when prescribing sedatives to frail older adults, who are most vulnerable to adverse drug reactions and adverse health outcomes.
OBJECTIVE: To explore the association between use of sedative drugs and frailty. DESIGN: Cross-sectional study. SETTING: First wave of The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort of the community-dwelling population aged 50 years or older in Ireland. PARTICIPANTS: Participants were 1642 men and 1804 women aged 65 years or older. MEASUREMENTS: Regular use of sedative drugs determined according to the sedative load (SL) model, frailty phenotype status, and frailty deficit index (FI) score assessed using validated, established protocols. RESULTS: Overall, 19% of the participants took sedative drugs, most frequently hypnotics and antidepressants. Sedative drug use was at 46% for frail, 23% for prefrail, and 9% for nonfrail participants. After adjustment for covariates, SL was positively associated with being prefrail (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.11-1.46) and frail (OR 1.30; 95% CI 1.02-1.64). Advancing age but not sex remained significant (P < .001). After adjustment for covariates, the association between SL and the FI was also significant at P ≤ .001 (β = 1.77; 95% CI 1.13-2.42). CONCLUSION: Higher SL was positively associated with phenotype frailty and the FI. This suggests that careful consideration must be given when prescribing sedatives to frail older adults, who are most vulnerable to adverse drug reactions and adverse health outcomes.
Authors: João Apóstolo; Richard Cooke; Elzbieta Bobrowicz-Campos; Silvina Santana; Maura Marcucci; Antonio Cano; Miriam Vollenbroek-Hutten; Federico Germini; Barbara D'Avanzo; Holly Gwyther; Carol Holland Journal: JBI Database System Rev Implement Rep Date: 2018-01
Authors: João Apóstolo; Richard Cooke; Elzbieta Bobrowicz-Campos; Silvina Santana; Maura Marcucci; Antonio Cano; Miriam Vollenbroek-Hutten; Federico Germini; Barbara D'Avanzo; Holly Gwyther; Carol Holland Journal: JBI Database System Rev Implement Rep Date: 2018-05
Authors: David B Hogan; Colleen J Maxwell; Jonathan Afilalo; Rakesh C Arora; Sean M Bagshaw; Jenny Basran; Howard Bergman; Susan E Bronskill; Caitlin A Carter; Elijah Dixon; Brenda Hemmelgarn; Kenneth Madden; Arnold Mitnitski; Darryl Rolfson; Henry T Stelfox; Helen Tam-Tham; Hannah Wunsch Journal: Can Geriatr J Date: 2017-03-31
Authors: Jure Peklar; Mitja Kos; Máire O'Dwyer; Mary McCarron; Philip McCallion; Rose Anne Kenny; Martin C Henman Journal: PLoS One Date: 2017-09-06 Impact factor: 3.240