Patompong Ungprasert1, Matthew J Koster2, Kenneth J Warrington2. 1. Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905. Electronic address: Ungprasert.Patompong@mayo.edu. 2. Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Abstract
OBJECTIVE: To investigate the association between giant cell arteritis (GCA) and risk of coronary artery disease (CAD). METHODS: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, or standardized incidence ratios with 95% confidence interval comparing CAD risk in patients with GCA versus non-GCA controls. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. RESULT: Six studies with 10,868 patients with GCA and 245,323 controls were identified and included in our data analysis. The pooled risk ratio of CAD in patients with GCA was 1.51 and did not achieve statistical significance (95% CI: 0.88-2.61). The statistical heterogeneity was high with an I(2) of 97%. CONCLUSION: In contrast to other chronic systemic inflammatory disorders, our meta-analysis did not show any statistically significant increased risk of CAD among patients with GCA.
OBJECTIVE: To investigate the association between giant cell arteritis (GCA) and risk of coronary artery disease (CAD). METHODS: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, or standardized incidence ratios with 95% confidence interval comparing CAD risk in patients with GCA versus non-GCA controls. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. RESULT: Six studies with 10,868 patients with GCA and 245,323 controls were identified and included in our data analysis. The pooled risk ratio of CAD in patients with GCA was 1.51 and did not achieve statistical significance (95% CI: 0.88-2.61). The statistical heterogeneity was high with an I(2) of 97%. CONCLUSION: In contrast to other chronic systemic inflammatory disorders, our meta-analysis did not show any statistically significant increased risk of CAD among patients with GCA.
Authors: Max Yates; Robert Luben; Shabina Hayat; Sarah L Mackie; Richard A Watts; Kay-Tee Khaw; Nick J Wareham; Alex J MacGregor Journal: Rheumatology (Oxford) Date: 2020-02-01 Impact factor: 7.580
Authors: Shubhasree Banerjee; Mohammadhadi Bagheri; Veit Sandfort; Mark A Ahlman; Ashkan A Malayeri; David A Bluemke; Jianhua Yao; Peter C Grayson Journal: Semin Arthritis Rheum Date: 2018-09-17 Impact factor: 5.532
Authors: Lillian Armellin; Anthony Michael Sammel; Ben Ng; Kiran Sarathy; John Lambros; Taraneh Amir-Nezami; Shannon Dean Thomas; John Highton; Arvin Damodaran Journal: J Cardiol Cases Date: 2017-06-27