Literature DB >> 2543449

The urine from patients with peritonitis as a rich source for purifying human acid sphingomyelinase and other lysosomal enzymes.

L E Quintern1, T S Zenk, K Sandhoff.   

Abstract

Milligram amounts of human acid sphingomyelinase (EC 3.1.4.12) were purified to 95% homogeneity using urine from patients with acute peritonitis. The activity of this enzyme is elevated more than 200-times in the urine of these patients. To a lesser extent, levels of some other lysosomal hydrolases are also elevated.

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Year:  1989        PMID： 2543449     DOI： 10.1016/0005-2760(89)90244-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

Authors:  Russell W Jenkins; Jolanta Idkowiak-Baldys; Fabio Simbari; Daniel Canals; Patrick Roddy; Clarke D Riner; Christopher J Clarke; Yusuf A Hannun
Journal:  J Biol Chem       Date:  2010-11-22       Impact factor: 5.157

2.  Characterization of sphingomyelinase activity released by thrombin-stimulated platelets.

Authors:  E Romiti; V Vasta; E Meacci; M Farnararo; T Linke; K Ferlinz; K Sandhoff; P Bruni
Journal:  Mol Cell Biochem       Date:  2000-02       Impact factor: 3.396

3.  Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

Authors:  Susi Anheuser; Bernadette Breiden; Günter Schwarzmann; Konrad Sandhoff
Journal:  J Lipid Res       Date:  2015-07-14       Impact factor: 5.922

Review 4.  Roles and regulation of secretory and lysosomal acid sphingomyelinase.

Authors:  Russell W Jenkins; Daniel Canals; Yusuf A Hannun
Journal:  Cell Signal       Date:  2009-06       Impact factor: 4.315

5.  Occurrence of two molecular forms of human acid sphingomyelinase.

Authors:  K Ferlinz; R Hurwitz; G Vielhaber; K Suzuki; K Sandhoff
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857

Review 6.  My journey into the world of sphingolipids and sphingolipidoses.

Authors:  Konrad Sandhoff
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2012       Impact factor: 3.493

Review 7.  Keep Your Friends Close, but Your Enemies Closer: Role of Acid Sphingomyelinase During Infection and Host Response.

Authors:  Ha-Yeun Chung; Ralf A Claus
Journal:  Front Med (Lausanne)       Date:  2021-01-21

8.  Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.

Authors:  Jacob M Haus; Sangeeta R Kashyap; Takhar Kasumov; Renliang Zhang; Karen R Kelly; Ralph A Defronzo; John P Kirwan
Journal:  Diabetes       Date:  2008-11-13       Impact factor: 9.461
  8 in total

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