Literature DB >> 25434465

Sugar modification inhibits autophagosome-lysosome fusion.

Noboru Mizushima1.   

Abstract

Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25434465     DOI： 10.1038/ncb3078

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  6 in total

Review 1.  Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Authors:  Leigh A Baxt; Ramnik J Xavier
Journal:  Gastroenterology       Date:  2015-07-11       Impact factor: 22.682

2.  The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes.

Authors:  Takashi Nozawa; Atsuko Minowa-Nozawa; Chihiro Aikawa; Ichiro Nakagawa
Journal:  Autophagy       Date:  2016-10-28       Impact factor: 16.016

3.  Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes.

Authors:  Xiu-Tang Cheng; Bing Zhou; Mei-Yao Lin; Qian Cai; Zu-Hang Sheng
Journal:  J Cell Biol       Date:  2015-05-04       Impact factor: 10.539

4.  Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells.

Authors:  Jun Zhang; Xia Qin; Bin Wang; Ge Xu; Zhexue Qin; Jian Wang; Lanxiang Wu; Xiangwu Ju; Diptiman D Bose; Feng Qiu; Honghao Zhou; Zhen Zou
Journal:  Cell Death Dis       Date:  2017-07-27       Impact factor: 8.469

5.  SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor.

Authors:  Qiuyu Martin Zhu; Qiuyu Zhu; Munekazu Yamakuchi; Charles J Lowenstein
Journal:  PLoS One       Date:  2015-08-12       Impact factor: 3.240

6.  LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

Authors:  Virginie Hubert; Andrea Peschel; Brigitte Langer; Marion Gröger; Andrew Rees; Renate Kain
Journal:  Biol Open       Date:  2016-10-15       Impact factor: 2.422
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.