Literature DB >> 25434447

[Gastric cancer with liver metastasis and peritoneal dissemination treated with conversion surgery to achieve r0 resection after capecitabine, cisplatin, and trastuzumab chemotherapy-a case report].

Yasuhiro Choda1, Motoki Ninomiya, Takashi Kanazawa, Daisuke Sato, Noriaki Tokumoto, Masao Harano, Hiroyoshi Matsukawa, Yasutomo Ojima, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima.   

Abstract

Herein, we present a case report suggesting the importance of conversion surgery and the effectiveness of adjuvant chemotherapy with trastuzumab. A 77-year-old woman was diagnosed with gastric cancer complicated by multiple liver metastases and peritoneal dissemination. Owing to a HER2 immunohistochemistry (IHC) tumor score of 3+, we initiated capecitabine plus cisplatin (CDDP) plus trastuzumab chemotherapy. Subsequently, the liver metastases and peritoneal dissemination were absent on computed tomography images, and no new metastatic lesions developed during chemotherapy. After 10 chemotherapy courses, the patient underwent distal gastrectomy and 2 partial liver resection procedures. The liver metastasis remained, and it received a score of 2+ on the HER2 IHC test. We have continued to administer postoperative capecitabine plus trastuzumab chemotherapy because no metastatic lesions have appeared.

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Year:  2014        PMID: 25434447

Source DB:  PubMed          Journal:  Gan To Kagaku Ryoho        ISSN: 0385-0684


  1 in total

1.  Conversion therapy for advanced gastric cancer with trastuzumab combined with chemotherapy: A case report.

Authors:  Shuo-Meng Xiao; Rui Xu; Xiao-Li Tang; Zhi Ding; Ji-Man Li; Xiang Zhou
Journal:  Oncol Lett       Date:  2018-06-11       Impact factor: 2.967

  1 in total

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