Literature DB >> 25433984

EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: report of two cases and review of the literature.

Charles Ricordel1, Marie Labalette-Tiercin1, Alexandra Lespagnol2, Mallorie Kerjouan1, Catherine Dugast3, Jean Mosser2, Benoit Desrues1, Hervé Léna4.   

Abstract

We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and bearing germinal TP53 gene mutation, also known as Li-Fraumeni syndrome (LFS). We describe for the first time an EGFR-TKI resistance mutation in this population. Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database and from all the published cases of EGFR-mutated lung cancer in TP53 germline mutation carriers.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Epidermal growth factor receptor; Genetic predisposition to cancer; Li-Fraumeni syndrome; Molecular biology; Non-small cell lung cancer; Tyrosine kinase inhibitor

Mesh：

Substances：

Year:  2014        PMID： 25433984     DOI： 10.1016/j.lungcan.2014.11.005

Source DB:  PubMed          Journal:  Lung Cancer        ISSN： 0169-5002            Impact factor:   5.705


  9 in total

1.  Molecular diagnosis and clinical outcome of a lung cancer patient with TP53-E285K mutated Li-Fraumeni syndrome harboring a somatic EGFR-KDD mutation.

Authors:  Dafu Yang; Xue Han; Dan Li; Saiqiong Cui; Sisi Liu; Xue Wu; Zhaoxia Dai
Journal:  Am J Transl Res       Date:  2020-10-15       Impact factor: 4.060

2.  Breast Cancer Patient with Li-Fraumeni Syndrome: A Case Report Highlighting the Importance of Multidisciplinary Management.

Authors:  Beatriz Cirauqui; Teresa Morán; Anna Estival; Vanesa Quiroga; Olatz Etxaniz; Carmen Balana; Matilde Navarro; Salvador Villà; Rosa Ballester; Mireia Margelí
Journal:  Case Rep Oncol       Date:  2020-02-13

3.  Lung Cancer in Li-Fraumeni Syndrome.

Authors:  Kathleen Kerrigan; Jessica Chan; Jennie Vagher; Wendy Kohlmann; Anne Naumer; Jo Anson; Sara Low; Joshua Schiffman; Luke Maese
Journal:  JCO Precis Oncol       Date:  2021-03-23

Review 4.  Epidemiology and clinicopathological features of lung cancer in patients with prior history of breast cancer.

Authors:  Kevin Y Wang; James Newman; Chung-Shien Lee; Nagashree Seetharamu
Journal:  SAGE Open Med       Date:  2021-05-25

5.  Epidermal Growth Factor Receptor-mutated Lung Cancer as the Initial Manifestation of Germline TP53 Mutation Associated Cancer.

Authors:  Surabhi Pathak; Sunny R K Singh; Vatsala Katiyar; Susan Mcdunn
Journal:  Cureus       Date:  2018-03-30

Review 6.  Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

Authors:  Yue I Cheng; Yun Cui Gan; Dan Liu; Michael P A Davies; Wei Min Li; John K Field
Journal:  BMC Cancer       Date:  2019-11-08       Impact factor: 4.430

7.  Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?

Authors:  Igor Araujo Vieira; Tiago Finger Andreis; Bruna Vieira Fernandes; Maria Isabel Achatz; Gabriel S Macedo; Daniel Schramek; Patricia Ashton-Prolla
Journal:  Front Genet       Date:  2021-02-02       Impact factor: 4.599

8.  Evaluation of anti-EGFR-iRGD recombinant protein with GOLD nanoparticles: synergistic effect on antitumor efficiency using optimized deep neural networks.

Authors:  Aman Chandra Kaushik; Yan-Jing Wang; Xiangeng Wang; Ajay Kumar; Satya P Singh; Cheng-Tang Pan; Yow-Ling Shiue; Dong-Qing Wei
Journal:  RSC Adv       Date:  2019-06-19       Impact factor: 4.036

9.  Germline TP53 Mutation and Clinical Characteristics of Korean Patients With Li-Fraumeni Syndrome.

Authors:  Kyoung Jin Park; Hyun Jung Choi; Soon Pal Suh; Chang Seok Ki; Jong Won Kim
Journal:  Ann Lab Med       Date:  2016-09       Impact factor: 3.464
  9 in total

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