Literature DB >> 25433960

Metabolic and inflammatory genes in schizophrenia.

Kayla A Chase1, Cherise Rosen1, Hannah Gin1, Olivia Bjorkquist1, Benjamin Feiner1, Robert Marvin1, Sean Conrin1, Rajiv P Sharma2.   

Abstract

Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Inflammation; Obesity; Schizophrenia

Mesh：

Substances：

Year:  2014        PMID： 25433960      PMCID： PMC4276033          DOI： 10.1016/j.psychres.2014.11.007

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  41 in total

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