D Debieuvre1, C Locher2, A-C Neidhardt3, F Goupil4, B Lemaire5, A-S Blanchet-Legens6, D Renault7, J-Y Tavernier8, P Tagu9, H Mahmoud10, M Figueredo11, M Grivaux2. 1. Service de pneumologie, hôpital Émile-Muller, 20, avenue du Docteur-René-Laennec, 68070 Mulhouse, France. Electronic address: debieuvred@ch-mulhouse.fr. 2. Service de pneumologie, centre hospitalier, 77104 Meaux, France. 3. Service de pneumologie, hôpital Émile-Muller, 20, avenue du Docteur-René-Laennec, 68070 Mulhouse, France. 4. Service de pneumologie, unité 3, centre hospitalier, 72037 Le Mans, France. 5. Service de pneumologie, centre hospitalier, 45000 Orléans, France. 6. Service de pneumologie, centre Saint-Joseph-Saint-Luc, 69365 Lyon, France. 7. Service de pneumologie, centre hospitalier des Pays-de-Morlaix, 29600 Morlaix, France. 8. Service de pneumologie-allergologie, centre hospitalier, 59507 Douai, France. 9. Service de pneumologie, centre hospitalier, 55012 Bar-Le-Duc, France. 10. Service de pneumologie-oncologie thoracique, centre hospitalier intercommunal, 27023 Evreux, France. 11. Service de pneumologie et allergologie, centre hospitalier, 06130 Grasse, France.
Abstract
INTRODUCTION: Comparison by sex and presenting features between 2000 and 2010 of the characteristics of new cases of non-small-cell lung cancer (NSCLC). METHODS: Observational KBP-2010-CPHG study similar to KBP-2000-CPHG. Both studies were promoted by the French College of General Hospital Respiratory Physicians (CPHG). KBP-2010-CPHG collected data for 6083 NSCLC diagnosed between January 1st and December 31st, 2010, and followed in the respiratory departments of 119 French general hospitals. RESULTS: In 2010, 24.4 % of the patients were women (16 % in 2000, p<0.0001). Compared to men, women were more commonly non-smokers (34.2 vs 4.7 %) or lighter consumers (37.2 vs 43.7 pack per years) (p<0.0001). Their tumours (mostly adenocarcinoma: 64.6 vs 48.7 %, p<0.0001) were more frequently diagnosed at stage IV (62.4 vs 56.9 %, p=0.0008). EGFR mutation research was more frequently performed (48.5 vs 31.0 %, p<0.0001) and positive (20.6 vs 5.2 %, p<0.0001) in women than men. Their treatment more frequently included targeted therapy (13.4 vs 5.7 %, p<0.0001). Compared to 2000, the percentage of non-smokers increased in men (4.7 vs 2.5 %, p<0.0001) while remaining stable in women (36.1 vs 34.2 %, p=0.32). The percentage of adenocarcinomas increased, particularly in men (48.7 vs 31.5 %, p<0.0001). CONCLUSIONS: The percentage of women with NSCLC has increased in 10years in France. In 2010, the main gender differences persist, but have decreased with the increasing proportion of non-smokers and adenocarcinomas in men. Various hypotheses to explain these changes are discussed.
INTRODUCTION: Comparison by sex and presenting features between 2000 and 2010 of the characteristics of new cases of non-small-cell lung cancer (NSCLC). METHODS: Observational KBP-2010-CPHG study similar to KBP-2000-CPHG. Both studies were promoted by the French College of General Hospital Respiratory Physicians (CPHG). KBP-2010-CPHG collected data for 6083 NSCLC diagnosed between January 1st and December 31st, 2010, and followed in the respiratory departments of 119 French general hospitals. RESULTS: In 2010, 24.4 % of the patients were women (16 % in 2000, p<0.0001). Compared to men, women were more commonly non-smokers (34.2 vs 4.7 %) or lighter consumers (37.2 vs 43.7 pack per years) (p<0.0001). Their tumours (mostly adenocarcinoma: 64.6 vs 48.7 %, p<0.0001) were more frequently diagnosed at stage IV (62.4 vs 56.9 %, p=0.0008). EGFR mutation research was more frequently performed (48.5 vs 31.0 %, p<0.0001) and positive (20.6 vs 5.2 %, p<0.0001) in women than men. Their treatment more frequently included targeted therapy (13.4 vs 5.7 %, p<0.0001). Compared to 2000, the percentage of non-smokers increased in men (4.7 vs 2.5 %, p<0.0001) while remaining stable in women (36.1 vs 34.2 %, p=0.32). The percentage of adenocarcinomas increased, particularly in men (48.7 vs 31.5 %, p<0.0001). CONCLUSIONS: The percentage of women with NSCLC has increased in 10years in France. In 2010, the main gender differences persist, but have decreased with the increasing proportion of non-smokers and adenocarcinomas in men. Various hypotheses to explain these changes are discussed.
Keywords:
Adenocarcinoma; Adénocarcinome; Cancer bronchique non à petites cellules (CBNPC); Epidemiology; France; Non-small-cell lung cancer (NSCLC); Sex; Sexe; Épidémiologie
Authors: N Belloumi; H Baili; M Abdennadher; C Habbouria; I Bachouch; I Bouassida; S Zairi; F Chermiti Ben Abdallah; S Fenniche; H Zribi; A Marghli Journal: Case Rep Surg Date: 2021-07-02
Authors: Valéry Refeno; Nomeharisoa Rodrigue Emile Hasiniatsy; Ny Ony Tiana Florence Andrianandrasana; Andriatsihoarana Voahary Nasandratriniavo Ramahandrisoa; Jean Marc Rakotonarivo; Joée Larissa Maevazaka; Hanitrala Jean Louis Rakotovao; Florine Rafaramino Journal: Pan Afr Med J Date: 2015-11-20
Authors: Clémence Legoupil; Didier Debieuvre; Aurelien Marabelle; Stefan Michiels; Raïssa Kapso; Benjamin Besse; Julia Bonastre Journal: ERJ Open Res Date: 2020-04-19