| Literature DB >> 25433459 |
Laura Serra1, Massimo Musicco2, Mara Cercignani3, Mario Torso1, Barbara Spanò1, Chiara Mastropasqua1, Giovanni Giulietti1, Camillo Marra4, Giuseppe Bruno5, Giacomo Koch6, Carlo Caltagirone6, Marco Bozzali7.
Abstract
This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.Entities:
Keywords: AD; Cognitive reserve; MTA; Relative risk; White matter lesions; a-MCI
Mesh：
Year: 2014 PMID： 25433459 DOI： 10.1016/j.neurobiolaging.2014.10.010
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673