Colleen S Chun1, Sheila Weinmann2, Karen Riedlinger3, John P Mullooly4. 1. Pediatric Infectious Diseases Specialist for Northwest Permanente in Portland, OR. colleen.chun@kp.org. 2. Investigator at the Center for Health Research in Portland, OR. sheila.weinmann@kpchr.org. 3. Retired Senior Research Network Consultant for the Center for Health Research in Portland, OR. spakk@comcast.net. 4. Emeritus Senior Investigator for the Center for Health Research in Portland, OR. mullooly@comcast.net.
Abstract
OBJECTIVE: To investigate whether passive cigarette smoke exposure increases the risk of invasive pneumococcal disease in children. METHODS: In a population-based case-control study, 171 children aged 0 to 12 years with culture-confirmed invasive pneumococcal disease during the years 1994 to 2004 were identified. Two controls were matched to each case on age and patterns of Health Plan membership. We reviewed medical records of subjects and family members for information on household cigarette smoke exposure within 2 years of the diagnosis of invasive pneumococcal disease. We collected information on sex, race, pneumococcal vaccination, selected medical conditions, and medications in the 3 months before the diagnosis. RESULTS: Similar proportions of cases (25%) and controls (30%) had definite or probable passive smoke exposure (odds ratio [OR] = 0.76, 95% confidence interval [CI] = 0.47-1.2). Cases of invasive pneumococcal disease were more likely to be nonwhite than controls (OR = 4.4, 95% CI = 2.3-8.2). Elevated risk of invasive pneumococcal disease was found in subjects with recent pulmonary diagnoses (OR = 2.2, 95% CI = 1.2-4.0) and recent antibiotic use (OR = 1.6, 95% CI = 1.1-2.3). CONCLUSIONS: Passive cigarette smoke exposure was not associated with invasive pneumococcal disease in this pediatric population. Invasive pneumococcal disease was associated with recent pulmonary diagnoses and recent antibiotic use.
OBJECTIVE: To investigate whether passive cigarette smoke exposure increases the risk of invasive pneumococcal disease in children. METHODS: In a population-based case-control study, 171 children aged 0 to 12 years with culture-confirmed invasive pneumococcal disease during the years 1994 to 2004 were identified. Two controls were matched to each case on age and patterns of Health Plan membership. We reviewed medical records of subjects and family members for information on household cigarette smoke exposure within 2 years of the diagnosis of invasive pneumococcal disease. We collected information on sex, race, pneumococcal vaccination, selected medical conditions, and medications in the 3 months before the diagnosis. RESULTS: Similar proportions of cases (25%) and controls (30%) had definite or probable passive smoke exposure (odds ratio [OR] = 0.76, 95% confidence interval [CI] = 0.47-1.2). Cases of invasive pneumococcal disease were more likely to be nonwhite than controls (OR = 4.4, 95% CI = 2.3-8.2). Elevated risk of invasive pneumococcal disease was found in subjects with recent pulmonary diagnoses (OR = 2.2, 95% CI = 1.2-4.0) and recent antibiotic use (OR = 1.6, 95% CI = 1.1-2.3). CONCLUSIONS: Passive cigarette smoke exposure was not associated with invasive pneumococcal disease in this pediatric population. Invasive pneumococcal disease was associated with recent pulmonary diagnoses and recent antibiotic use.
Authors: J P Nuorti; J C Butler; M M Farley; L H Harrison; A McGeer; M S Kolczak; R F Breiman Journal: N Engl J Med Date: 2000-03-09 Impact factor: 91.245
Authors: Lie-Hong Chen; Virginia Quinn; Lanfang Xu; Michael K Gould; Steven J Jacobsen; Corinna Koebnick; Kristi Reynolds; Rulin C Hechter; Chun R Chao Journal: Subst Use Misuse Date: 2013-04-26 Impact factor: 2.164
Authors: T J O'Dempsey; T F McArdle; J Morris; N Lloyd-Evans; I Baldeh; B E Laurence; O Secka; B M Greenwood Journal: Int J Epidemiol Date: 1996-08 Impact factor: 7.196
Authors: Thomas R Talbot; Tina V Hartert; Ed Mitchel; Natasha B Halasa; Patrick G Arbogast; Katherine A Poehling; William Schaffner; Allen S Craig; Marie R Griffin Journal: N Engl J Med Date: 2005-05-19 Impact factor: 91.245
Authors: Lessandra Michelin; Fernanda M Weber; Bruna W Scolari; Bruna K Menezes; Maria Carolina Gullo Journal: J Bras Pneumol Date: 2019-10-17 Impact factor: 2.624