Zuzana Walker1, Emilio Moreno1, Alan Thomas1, Fraser Inglis1, Naji Tabet1, Michael Rainer1, Gilberto Pizzolato1, Alessandro Padovani1. 1. Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK; Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK; Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK; Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK; Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK; Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis- und Alzheimerforschung, Vienna, Austria; Gilberto Pizzolato (deceased), MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Alessandro Padovani, MD, PhD, Scienze Cliniche e Sperimentali, University of Brescia, Brescia, Italy.
Abstract
BACKGROUND:Dementia with Lewy bodies (DLB) is underrecognised in clinical settings. AIMS: To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia). METHOD: We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB. RESULTS: There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%). CONCLUSIONS: Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB. Royal College of Psychiatrists.
RCT Entities:
BACKGROUND:Dementia with Lewy bodies (DLB) is underrecognised in clinical settings. AIMS: To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia). METHOD: We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB. RESULTS: There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%). CONCLUSIONS: Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB. Royal College of Psychiatrists.
Authors: L Bonanni; A Cagnin; F Agosta; C Babiloni; B Borroni; M Bozzali; A C Bruni; M Filippi; D Galimberti; R Monastero; C Muscio; L Parnetti; D Perani; L Serra; V Silani; P Tiraboschi; A Padovani Journal: Neurol Sci Date: 2016-09-13 Impact factor: 3.307
Authors: Enrico Premi; V D Calhoun; V Garibotto; R Turrone; A Alberici; E Cottini; A Pilotto; S Gazzina; M Magoni; B Paghera; B Borroni; A Padovani Journal: Mol Imaging Biol Date: 2017-10 Impact factor: 3.488