Literature DB >> 2543131

A syncytia assay for human immunodeficiency virus type I (HIV-I) envelope protein and its use in studying HIV-I mutations.

J M Felser1, T Klimkait, J Silver.   

Abstract

We describe a syncytia assay that utilizes a noninfectious plasmid (pEVd1443) derived from human immunodeficiency virus type I (HIV-I). This plasmid carries a large deletion of gag-pol sequences but expresses HIV-I envelope proteins and induces syncytia following transfection into HeLa-CD4 cells. This plasmid was used to study the effects of mutations in the gp 120 and gp41 portions of the envelope gene of HIV-I.

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Year:  1989        PMID： 2543131     DOI： 10.1016/0042-6822(89)90448-0

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  25 in total

1.  Conformational partitioning of the fusion peptide of HIV-1 gp41 and its structural analogs in bilayer membranes.

Authors:  Michael W Maddox; Marjorie L Longo
Journal:  Biophys J       Date:  2002-12       Impact factor: 4.033

2.  Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.

Authors:  E O Freed; D J Myers; R Risser
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

3.  Mutational analysis of the fusion peptide of Moloney murine leukemia virus transmembrane protein p15E.

Authors:  N L Zhu; P M Cannon; D Chen; W F Anderson
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

4.  Inhibition of murine leukemia virus envelope protein (env) processing by intracellular expression of the env N-terminal heptad repeat region.

Authors:  Wu Ou; Jonathan Silver
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

5.  Spontaneous reversion of human immunodeficiency virus type 1 neutralization-resistant variant HXB2thr582: in vitro selection against cytopathicity highlights gp120-gp41 interactive regions.

Authors:  T L Stern; M S Reitz; M Robert-Guroff
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

6.  The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner.

Authors:  Dimiter G Demirov; Jan M Orenstein; Eric O Freed
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

7.  Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

Authors:  J B Kopp; M E Klotman; S H Adler; L A Bruggeman; P Dickie; N J Marinos; M Eckhaus; J L Bryant; A L Notkins; P E Klotman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

8.  3'-Azido-3'-deoxythymidine-induced reduction in the ability of uninfected CD4-expressing cells to participate in syncytium formation.

Authors:  R W Buckheit; J Germany-Decker; K Qualls-Goodwin; B J Bowdon; W M Shannon
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

9.  Truncation of the human immunodeficiency virus type 1 transmembrane glycoprotein cytoplasmic domain blocks virus infectivity.

Authors:  J W Dubay; S J Roberts; B H Hahn; E Hunter
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

10.  Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions.

Authors:  E O Freed; M A Martin
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103
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