Kegong Ji1, Zhitong Zheng, Zhixun Wang, Liming Zhang. 1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA (USA) http://www.chem.ucsb.edu/∼zhang/index.html; Current address: College of Science, Northwest A&F University, 3 Taicheng Road, Yangling 712100, Shaanxi (China).
Abstract
A newly developed P,N-bidentate ligand enables enantioselective intramolecular cyclopropanation by a reactive α-oxo gold carbene intermediate generated in situ. The ligand design is based on our previously proposed structure (with a well-organized triscoordinated gold center) of the carbene intermediate in the presence of a P,N-bidentate ligand. A C2-symmetric piperidine ring was incorporated in the ligand as the nitrogen-containing moiety. A range of racemic transformations of α-oxo gold carbene intermediates have been developed recently, and this new class of chiral ligands could enable their modification for asymmetric synthesis, as demonstrated in this study.
A newly developed n class="Chemical">P,N-bidentate ligand enables enantioselective inpan>tramolecular cyclopropanation by a reactive α-oxo gold n class="Chemical">carbene intermediate generated in situ. The ligand design is based on our previously proposed structure (with a well-organized triscoordinated gold center) of the carbene intermediate in the presence of a P,N-bidentate ligand. A C2-symmetric piperidine ring was incorporated in the ligand as the nitrogen-containing moiety. A range of racemic transformations of α-oxo gold carbene intermediates have been developed recently, and this new class of chiral ligands could enable their modification for asymmetric synthesis, as demonstrated in this study.
Authors: D D Schoepp; B G Johnson; R A Wright; C R Salhoff; N G Mayne; S Wu; S L Cockerman; J P Burnett; R Belegaje; D Bleakman; J A Monn Journal: Neuropharmacology Date: 1997-01 Impact factor: 5.250
Authors: Mark K Rong; Koen van Duin; Tom van Dijk; Jeroen J M de Pater; Berth-Jan Deelman; Martin Nieger; A W Ehlers; J Chris Slootweg; Koop Lammertsma Journal: Organometallics Date: 2017-02-16 Impact factor: 3.876