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Literature DB >> 25431159

Synovial joints: from development to homeostasis.

Lara Longobardi¹, Tieshi Li, Lidia Tagliafierro, Joseph D Temple, Helen H Willcockson, Ping Ye, Alessandra Esposito, Fuhua Xu, Anna Spagnoli.

Abstract

Synovial joint morphogenesis occurs through the condensation of mesenchymal cells into a non-cartilaginous region known as the interzone and the specification of progenitor cells that commit to the articular fate. Although several signaling molecules are expressed by the interzone, the mechanism is poorly understood. For treatments of cartilage injuries, it is critical to discover the presence of joint progenitor cells in adult tissues and their expression gene pattern. Potential stem cell niches have been found in different joint regions, such as the surface zone of articular cartilage, synovium, and groove of Ranvier. Inherited joint malformations as well as joint-degenerating conditions are often associated with other skeletal defects and may be seen as the failure of morphogenic factors to establish the correct microenvironment in cartilage and bone. Therefore, exploring how joints form can help us understand how cartilage and bone are damaged and develop drugs to reactivate this developing mechanism.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 25431159 PMCID： PMC4306636 DOI： 10.1007/s11914-014-0247-7

Source DB: PubMed Journal: Curr Osteoporos Rep ISSN： 1544-1873 Impact factor: 5.096

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11 in total

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Authors: Minwook Kim; Eiki Koyama; Cheri M Saunders; William Querido; Nancy Pleshko; Maurizio Pacifici
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Authors: Danielle Rux; Kimberly Helbig; Eiki Koyama; Maurizio Pacifici
Journal: Dev Biol Date: 2021-05-16 Impact factor: 3.148