Literature DB >> 25430645

Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.

D A Zhebrun1, Areg A Totolyan, A L Maslyanskii, A G Titov, A P Patrukhin, A A Kostareva, I S Gol'tseva.   

Abstract

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.

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Year:  2014        PMID： 25430645     DOI： 10.1007/s10517-014-2720-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

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