Literature DB >> 25430427

Extending the donor pool: rehabilitation of poor organs.

Marcelo Cypel1, Shaf Keshavjee2.   

Abstract

The number of patients listed for lung transplantation exceeds the number of available transplantable organs because of a shortage of organ donors and a low utilization rate of donated lungs. A novel strategy of donor lung management, called ex vivo lung perfusion (EVLP) can keep the organ in a physiologic protective condition, and promises to increase lung utilization by reevaluating, treating, and repairing donor lungs before transplantation. Preclinical studies have shown great potential for EVLP as a platform for the delivery of novel therapies to repair injured organs ex vivo and improve the success of lung transplantation.

Entities:  

Keywords:  Ex vivo lung perfusion; Lung transplantation; Organ preservation

Mesh：

Substances：

Year:  2015        PMID： 25430427     DOI： 10.1016/j.thorsurg.2014.09.002

Source DB:  PubMed          Journal:  Thorac Surg Clin            Impact factor:   1.750


  16 in total

Review 1.  History of lung transplantation.

Authors:  Federico Venuta; Dirk Van Raemdonck
Journal:  J Thorac Dis       Date:  2017-12       Impact factor: 2.895

2.  A Critical Role for Airway Microvessels in Lung Transplantation.

Authors:  Mark R Nicolls; Gundeep S Dhillon; Niccolò Daddi
Journal:  Am J Respir Crit Care Med       Date:  2016-03-01       Impact factor: 21.405

Review 3.  Machine perfusion of thoracic organs.

Authors:  Dirk Van Raemdonck; Filip Rega; Steffen Rex; Arne Neyrinck
Journal:  J Thorac Dis       Date:  2018-04       Impact factor: 2.895

4.  Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism.

Authors:  Eric J Charles; J Hunter Mehaffey; Ashish K Sharma; Yunge Zhao; Mark H Stoler; James M Isbell; Christine L Lau; Curtis G Tribble; Victor E Laubach; Irving L Kron
Journal:  J Thorac Cardiovasc Surg       Date:  2017-04-12       Impact factor: 5.209

5.  Cell replacement in human lung bioengineering.

Authors:  Brandon A Guenthart; John D O'Neill; Jinho Kim; Kenmond Fung; Gordana Vunjak-Novakovic; Matthew Bacchetta
Journal:  J Heart Lung Transplant       Date:  2018-11-22       Impact factor: 10.247

6.  Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion.

Authors:  Eric J Charles; Mary E Huerter; Cynthia E Wagner; Ashish K Sharma; Yunge Zhao; Mark H Stoler; J Hunter Mehaffey; James M Isbell; Christine L Lau; Curtis G Tribble; Victor E Laubach; Irving L Kron
Journal:  Ann Thorac Surg       Date:  2016-09-07       Impact factor: 4.330

Review 7.  Cardiac allograft vasculopathy: a donor or recipient induced pathology?

Authors:  Patricia van den Hoogen; Manon M H Huibers; Joost P G Sluijter; Roel A de Weger
Journal:  J Cardiovasc Transl Res       Date:  2015-02-05       Impact factor: 4.132

8.  A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury.

Authors:  An Martens; Sofie Ordies; Bart M Vanaudenaerde; Stijn E Verleden; Robin Vos; Geert M Verleden; Eric K Verbeken; Dirk E Van Raemdonck; Sandra Claes; Dominique Schols; Matthieu Chalopin; Ira Katz; Geraldine Farjot; Arne P Neyrinck
Journal:  Med Gas Res       Date:  2017-03-30

9.  Bridging the survival gap in cystic fibrosis: An investigation of lung transplant outcomes in Canada and the United States.

Authors:  Anne L Stephenson; Kathleen J Ramos; Jenna Sykes; Xiayi Ma; Sanja Stanojevic; Bradley S Quon; Bruce C Marshall; Kristofer Petren; Joshua S Ostrenga; Aliza K Fink; Albert Faro; Alexander Elbert; Cecilia Chaparro; Christopher H Goss
Journal:  J Heart Lung Transplant       Date:  2020-12-07       Impact factor: 10.247

Review 10.  Ischemia-Reperfusion Injury in Lung Transplantation.

Authors:  Toyofumi Fengshi Chen-Yoshikawa
Journal:  Cells       Date:  2021-05-28       Impact factor: 6.600
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