Literature DB >> 2542969

Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.

C D Blackstone1, S Supattapone, S H Snyder.   

Abstract

In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.

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Year:  1989        PMID： 2542969      PMCID： PMC287443          DOI： 10.1073/pnas.86.11.4316

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

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Authors:  M Wassef; J P Zanetta; A Brehier; C Sotelo
Journal:  Dev Biol       Date:  1985-09       Impact factor: 3.582

2.  Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors.

Authors:  J W Ferkany; R Zaczek; J T Coyle
Journal:  Nature       Date:  1982-08-19       Impact factor: 49.962

3.  Inositol phospholipid hydrolysis in rat cerebral cortical slices: II. Calcium requirement.

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Journal:  J Neurochem       Date:  1984-05       Impact factor: 5.372

4.  Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

Authors:  F Nicoletti; M J Iadarola; J T Wroblewski; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

5.  Glutamate stimulates inositol phosphate formation in striatal neurones.

Authors:  F Sladeczek; J P Pin; M Récasens; J Bockaert; S Weiss
Journal:  Nature       Date:  1985 Oct 24-30       Impact factor: 49.962

6.  Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus.

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Journal:  J Neurochem       Date:  1986-01       Impact factor: 5.372

7.  Pharmacological evidence for L-aspartate as the neurotransmitter of cerebellar climbing fibres in the guinea-pig.

Authors:  H Kimura; K Okamoto; Y Sakai
Journal:  J Physiol       Date:  1985-08       Impact factor: 5.182

Review 8.  Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors.

Authors:  A C Foster; G E Fagg
Journal:  Brain Res       Date:  1984-05       Impact factor: 3.252

9.  Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

Authors:  M J Berridge; C P Downes; M R Hanley
Journal:  Biochem J       Date:  1982-09-15       Impact factor: 3.857

10.  Calcium-binding protein in the developing rat cerebellum. An immunocytochemical study.

Authors:  C Legrand; M Thomasset; C O Parkes; M C Clavel; A Rabié
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249
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  18 in total

1.  Differential responsiveness of metabotropic glutamate receptors coupled to phosphoinositide hydrolysis to agonists in various brain areas of the adult rat.

Authors:  P Lorenzini; G M Bisso; S Fortuna; H Michalek
Journal:  Neurochem Res       Date:  1996-03       Impact factor: 3.996

2.  Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

Authors:  C A Ross; S K Danoff; M J Schell; S H Snyder; A Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

3.  Role of calcium in regulation of phosphoinositide signaling pathway.

Authors:  J Patel; R A Keith; A I Salama; W C Moore
Journal:  J Mol Neurosci       Date:  1991       Impact factor: 3.444

4.  Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro.

Authors:  F Crepel; D Jaillard
Journal:  J Physiol       Date:  1991-01       Impact factor: 5.182

5.  Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response.

Authors:  J C Fiala; S Grossberg; D Bullock
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

6.  Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

Authors:  M W MacCumber; C A Ross; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

7.  Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro.

Authors:  F Crepel; H Daniel; N Hemart; D Jaillard
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

8.  Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

Review 9.  Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?

Authors:  Emmet M Power; Natalya A English; Ruth M Empson
Journal:  J Physiol       Date:  2016-02-24       Impact factor: 5.182

10.  Coactivation of metabotropic glutamate receptors and of voltage-gated calcium channels induces long-term depression in cerebellar Purkinje cells in vitro.

Authors:  H Daniel; N Hemart; D Jaillard; F Crepel
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972
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