Literature DB >> 25429662

A mini review on biological activities of pyridazinone derivatives as antiulcer, antisecretory, antihistamine and particularly against histamine H3R.

Mohammad Asif1.   

Abstract

Pyridazinone derivatives and their related analoges were introduced for gastric antiulcer and antisecretory activities. Selected compounds were applied to ulcer models and showed their antiulcer and anti secretary activities. Some pyridazinone compounds are recently reported as H3R antagonists. Some amine analogs of pyridazinones, pyridazinone- phenethylamines and 4,5-fused pyridazinones showed histamine H3R antagonist activity with significant affinity for rat and human H3R. These pyridazinone analogs also showed excellent selectivity and metabolic stability, with adequate pharmacokinetics.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25429662     DOI： 10.2174/1389557514666141127143133

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  6 in total

1.  Crystal structure and Hirshfeld surface analysis of ethyl 2-[5-(3-chloro-benz-yl)-6-oxo-3-phenyl-1,6-di-hydro-pyridazin-1-yl]acetate.

Authors:  Fouad El Kalai; Cemile Baydere; Said Daoui; Rafik Saddik; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-05-24

2.  A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation.

Authors:  Denisse A Gutierrez; Rebecca E DeJesus; Lisett Contreras; Isela A Rodriguez-Palomares; Paulina J Villanueva; Karol S Balderrama; Lenore Monterroza; Manuel Larragoity; Armando Varela-Ramirez; Renato J Aguilera
Journal:  Cell Biol Toxicol       Date:  2019-03-01       Impact factor: 6.691

3.  Crystal structures and Hirshfeld surface analyses of 4-benzyl-6-phenyl-4,5-di-hydro-pyridazin-3(2H)-one and methyl 2-[5-(2,6-di-chloro-benz-yl)-6-oxo-3-phenyl-1,4,5,6-tetra-hydropyridazin-1-yl]acetate.

Authors:  Said Dadou; Sevgi Kansiz; Said Daoui; Fouad El Kalai; Cemile Baydere; Rafik Saddik; Khalid Karrouchi; Necmi Dege; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-22

4.  Crystal structure and Hirshfeld surface analysis of (E)-6-(4-hy-droxy-3-meth-oxy-styr-yl)-4,5-di-hydro-pyridazin-3(2H)-one.

Authors:  Said Daoui; Cemile Baydere; Fouad El Kalai; Rafik Saddik; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-31

5.  Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo.

Authors:  Aurélie Moniot; Julien Braux; Camille Bour; Christine Guillaume; Fabien Lamret; Ingrid Allart-Simon; Sandra Audonnet; Sarah Renault; Francoise Rédini; Marie Laronze-Cochard; Janos Sapi; Sophie C Gangloff; Stéphane Gérard; Frédéric Velard
Journal:  Cancers (Basel)       Date:  2021-11-28       Impact factor: 6.639

6.  Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids.

Authors:  Mohammad F Hassan; Abdul Rauf; Asif Sherwani; Mohammad Owais
Journal:  Sci Pharm       Date:  2015-06-09
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.