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Literature DB >> 2542957

Simian virus 40 (SV40) large tumor antigen causes stepwise changes in SV40 origin structure during initiation of DNA replication.

Abstract

We have studied structural changes in the simian virus 40 (SV40) replication origin induced by SV40 large tumor antigen (T antigen). T-antigen-induced changes in origin DNA conformation can be visualized as specific and discrete topologic changes in origin DNA minicircles. We discovered three origin-T-antigen complexes defined by changes in DNA linking number. These complexes probably reflected essential early steps in the initiation of DNA replication since their formation required DNA sequences that are necessary for DNA replication but do not affect T-antigen binding. There are striking parallels between the T antigen-origin interactions uncovered by this assay and the interactions between the DnaA, -B, and -C proteins and the Escherichia coli replication origin, suggesting a significant evolutionary conservation in the mechanisms that initiate DNA replication.

Entities: Disease Species

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Year: 1989 PMID： 2542957 PMCID： PMC287363 DOI： 10.1073/pnas.86.11.3939

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

35 in total

1. Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter.

Authors: K Takahashi; M Vigneron; H Matthes; A Wildeman; M Zenke; P Chambon
Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

2. Transcription of Escherichia coli ara in vitro. The cyclic AMP receptor protein requirement for PBAD induction that depends on the presence and orientation of the araO2 site.

Authors: S Hahn; W Hendrickson; R Schleif
Journal: J Mol Biol Date: 1986-04-05 Impact factor: 5.469

10. Species-specific functional interactions of DNA polymerase alpha-primase with simian virus 40 (SV40) T antigen require SV40 origin DNA.

Authors: C Schneider; K Weisshart; L A Guarino; I Dornreiter; E Fanning
Journal: Mol Cell Biol Date: 1994-05 Impact factor: 4.272

Simian virus 40 (SV40) large tumor antigen causes stepwise changes in SV40 origin structure during initiation of DNA replication.

1. Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter.

2. Transcription of Escherichia coli ara in vitro. The cyclic AMP receptor protein requirement for PBAD induction that depends on the presence and orientation of the araO2 site.

3. Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells.

Review 4. Biochemical topology: applications to DNA recombination and replication.

5. Functional organization of the simian virus 40 origin of DNA replication.

6. Multiple DNA-protein interactions governing high-precision DNA transactions.

7. Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.

8. The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites.

9. Simian virus 40 DNA replication in vitro.

10. DNA helicase activity of SV40 large tumor antigen.

1. Simian virus 40 DNA replication in vitro: identification of multiple stages of initiation.

2. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.

3. Spacing is crucial for coordination of domain functions within the simian virus 40 core origin of replication.

4. The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.

5. Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro.

6. Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.

7. Relationship among location of T-antigen-induced DNA distortion, auxiliary sequences, and DNA replication efficiency.

8. Differential induction of structural changes in the simian virus 40 origin of replication by T antigen.

9. Hypoxia blocks in vivo initiation of simian virus 40 replication at a stage preceding origin unwinding.

10. Species-specific functional interactions of DNA polymerase alpha-primase with simian virus 40 (SV40) T antigen require SV40 origin DNA.