| Literature DB >> 25429064 |
Meian He1, Min Xu2, Ben Zhang3, Jun Liang4, Peng Chen5, Jong-Young Lee6, Todd A Johnson7, Huaixing Li8, Xiaobo Yang9, Juncheng Dai10, Liming Liang11, Lixuan Gui12, Qibin Qi11, Jinyan Huang11, Yanping Li11, Linda S Adair13, Tin Aung14, Qiuyin Cai3, Ching-Yu Cheng15, Myeong-Chan Cho6, Yoon Shin Cho6, Minjie Chu10, Bin Cui16, Yu-Tang Gao17, Min Jin Go6, Dongfeng Gu18, Weiqiong Gu16, Huan Guo12, Yongchen Hao18, Jie Hong16, Zhibin Hu10, Yanling Hu19, Jianfeng Huang18, Joo-Yeon Hwang6, Mohammad Kamran Ikram20, Guangfu Jin10, Dae-Hee Kang21, Chiea Chuen Khor22, Bong-Jo Kim6, Hung Tae Kim6, Michiaki Kubo23, Jeannette Lee5, Juyoung Lee6, Nanette R Lee24, Ruoying Li25, Jun Li12, JianJun Liu26, Jirong Longe3, Wei Lu27, Xiangfeng Lu18, Xiaoping Miao12, Yukinori Okada28, Rick Twee-Hee Ong5, Gaokun Qiu12, Mark Seielstad29, Xueling Sim30, Huaidong Song31, Fumihiko Takeuchi32, Toshihiro Tanaka33, Phil R Taylor34, Laiyuan Wang18, Weiqing Wang16, Yiqin Wang8, Chen Wu35, Ying Wu36, Yong-Bing Xiang17, Ken Yamamoto37, Handong Yang38, Ming Liao39, Mitsuhiro Yokota40, Terri Young41, Xiaomin Zhang12, Norihiro Kato32, Qing K Wang42, Wei Zheng3, Frank B Hu11, Dongxin Lin35, Hongbing Shen10, Yik Ying Teo43, Zengnan Mo39, Tien Yin Wong44, Xu Lin8, Karen L Mohlke36, Guang Ning16, Tatsuhiko Tsunoda7, Bok-Ghee Han6, Xiao-Ou Shu3, E Shyong Tai45, Tangchun Wu12, Lu Qi11.
Abstract
Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.Entities:
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Year: 2014 PMID： 25429064 PMCID： PMC4351379 DOI： 10.1093/hmg/ddu583
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150