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Literature DB >> 25428847

Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.

Adina Turcu¹, Joshua M Smith, Richard Auchus, William E Rainey.

Abstract

The human adrenal produces more 19 carbon (C19) steroids, by mass, than either glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C19 steroid biosynthesis continue to represent one of the most intriguing mysteries of endocrine physiology. This review will discuss the C19 steroids synthesized by the human adrenal and the features within the adrenal that allow production of these steroids. Finally, we consider the effects of these steroids in normal physiology and disorders of adrenal C19 steroid excess.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：
Androgens
Androstanes

Year: 2014 PMID： 25428847 PMCID： PMC4437668 DOI： 10.1002/cphy.c140006

Source DB: PubMed Journal: Compr Physiol ISSN： 2040-4603 Impact factor: 9.090

176 in total

Review 1. The human fetal adrenal: making adrenal androgens for placental estrogens.

Authors: William E Rainey; Khurram S Rehman; Bruce R Carr
Journal: Semin Reprod Med Date: 2004-11 Impact factor: 1.303

2. Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis.

Authors: Yasuhiro Nakamura; Peter J Hornsby; Peter Casson; Ryo Morimoto; Fumitoshi Satoh; Yewei Xing; Michael R Kennedy; Hironobu Sasano; William E Rainey
Journal: J Clin Endocrinol Metab Date: 2009-03-31 Impact factor: 5.958

Review 3. Regulation of the biosynthesis of steroidogenic enzymes.

Authors: E R Simpson; J I Mason; M E John; M X Zuber; R J Rodgers; M R Waterman
Journal: J Steroid Biochem Date: 1987 Impact factor: 4.292

4. Transcriptional regulation of steroid hydroxylase genes by corticotropin.

Authors: M E John; M C John; V Boggaram; E R Simpson; M R Waterman
Journal: Proc Natl Acad Sci U S A Date: 1986-07 Impact factor: 11.205

Review 5. Premature adrenarche--normal variant or forerunner of adult disease?

Authors: L Ibáñez; J Dimartino-Nardi; N Potau; P Saenger
Journal: Endocr Rev Date: 2000-12 Impact factor: 19.871

Review 6. Congenital adrenal hyperplasia owing to 3 beta-hydroxysteroid dehydrogenase deficiency.

Authors: S Pang
Journal: Endocrinol Metab Clin North Am Date: 2001-03 Impact factor: 4.741

7. Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency.

Authors: C E Fardella; L H Zhang; P Mahachoklertwattana; D Lin; W L Miller
Journal: J Clin Endocrinol Metab Date: 1993-08 Impact factor: 5.958

8. Congenital adrenal hyperplasia due to point mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene.

Authors: E Rhéaume; J Simard; Y Morel; F Mebarki; M Zachmann; M G Forest; M I New; F Labrie
Journal: Nat Genet Date: 1992-07 Impact factor: 38.330

9. Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins.

Authors: Zvi Granot; Ruth Geiss-Friedlander; Naomi Melamed-Book; Sarah Eimerl; Rina Timberg; Aryeh M Weiss; Karen H Hales; Dale B Hales; Douglas M Stocco; Joseph Orly
Journal: Mol Endocrinol Date: 2003-09-04

10. Familial glucocorticoid deficiency type 2: a case report.

Authors: Leyla Akın; Selim Kurtoğlu; Mustafa Kendirici; Mustafa Ali Akın
Journal: J Clin Res Pediatr Endocrinol Date: 2010-08-06

29 in total

1. Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.

Authors: Tianzhu Zang; Mary-Ellen Taplin; Daniel Tamae; Wanling Xie; Clementina Mesaros; Zhenwei Zhang; Glenn Bubley; Bruce Montgomery; Steven P Balk; Elahe A Mostaghel; Ian A Blair; Trevor M Penning
Journal: Endocr Relat Cancer Date: 2017-06-29 Impact factor: 5.678

Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.

Review 1. The human fetal adrenal: making adrenal androgens for placental estrogens.

2. Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis.

Review 3. Regulation of the biosynthesis of steroidogenic enzymes.

4. Transcriptional regulation of steroid hydroxylase genes by corticotropin.

Review 5. Premature adrenarche--normal variant or forerunner of adult disease?

Review 6. Congenital adrenal hyperplasia owing to 3 beta-hydroxysteroid dehydrogenase deficiency.

7. Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency.

8. Congenital adrenal hyperplasia due to point mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene.

9. Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins.

10. Familial glucocorticoid deficiency type 2: a case report.

1. Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.

2. 11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche.

3. Glucocorticoid replacement therapies: past, present and future.

Review 4. The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health.

5. Gonadal hormones affect alcohol drinking, but not cue+yohimbine-induced alcohol seeking, in male and female rats.

Review 6. The role of miRNAs in regulating adrenal and gonadal steroidogenesis.

7. Postmenopausal Androgen Metabolism and Endometrial Cancer Risk in the Women's Health Initiative Observational Study.

Review 8. Stem cell function and plasticity in the normal physiology of the adrenal cortex.

Review 9. Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis.

10. Circadian rhythms of 11-oxygenated C19 steroids and ∆5-steroid sulfates in healthy men.