Literature DB >> 2542742

A high molecular weight collagenase inhibitor made by rabbit chondrocytes in cell culture.

G M Morris1.   

Abstract

A new, high molecular weight (66,000 daltons) inhibitor of collagenase (LCI) has been isolated and partially characterized. It accounted for 20% of the collagenase-inhibitory activity in the supernatants of rabbit chondrocytes cultured in 10% acid-treated fetal bovine serum (ATFBS). LCI was stable to 60 degrees C and sensitive to reduction and alkylation. Unlike a low molecular weight collagenase inhibitor, similar to Tissue Inhibitor of Metallo-Proteinases (TIMP), it did not bind to concanavalin A-Sepharose 4B.

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Year:  1989        PMID： 2542742     DOI： 10.1016/s0934-8832(89)80030-7

Source DB:  PubMed          Journal:  Matrix        ISSN： 0934-8832


  5 in total

1.  Large inhibitor of metalloproteinases (LIMP) contains tissue inhibitor of metalloproteinases (TIMP)-2 bound to 72,000-M(r) progelatinase.

Authors:  V A Curry; I M Clark; H Bigg; T E Cawston
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

2.  Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase.

Authors:  T E Cawston; V A Curry; I M Clark; B L Hazleman
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

3.  Identification of tissue inhibitor of metalloproteinase-2 (TIMP-2)-progelatinase complex as the third metalloproteinase inhibitor peak in rheumatoid synovial fluid.

Authors:  T E Cawston; H F Bigg; I M Clark; B L Hazleman
Journal:  Ann Rheum Dis       Date:  1993-03       Impact factor: 19.103

4.  The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.

Authors:  R V Ward; R M Hembry; J J Reynolds; G Murphy
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

5.  Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes.

Authors:  M A Moses; J Sudhalter; R Langer
Journal:  J Cell Biol       Date:  1992-10       Impact factor: 10.539
  5 in total

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