Literature DB >> 2542711

Vanadate counteracts glucagon effects in isolated rat hepatocytes.

M Miralpeix1, J Gil, J L Rosa, J Carreras, R Bartrons.   

Abstract

The incubation of isolated rat hepatocytes with vanadate increased the concentration of fructose 2,6-bisphosphate without modifying 6-phosphofructo-2-kinase activity. Vanadate also reverted and prevented the decrease of fructose 2,6-bisphosphate levels, of the "active" form of the 6-phosphofructo 2-kinase and of the pyruvate kinase activity ratio produced by glucagon, by probably counteracting the increase in cyclic AMP concentration.

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Year:  1989        PMID: 2542711     DOI: 10.1016/0024-3205(89)90328-7

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  4 in total

1.  Oral administration of vanadate to streptozotocin-diabetic rats restores the glucose-induced activation of liver glycogen synthase.

Authors:  M Bollen; M Miralpeix; F Ventura; B Toth; R Bartrons; W Stalmans
Journal:  Biochem J       Date:  1990-04-01       Impact factor: 3.857

Review 2.  Membrane--vanadium interaction: a toxicokinetic evaluation.

Authors:  R K Upreti
Journal:  Mol Cell Biochem       Date:  1995 Dec 6-20       Impact factor: 3.396

3.  Vanadium salts stimulate mitogen-activated protein (MAP) kinases and ribosomal S6 kinases.

Authors:  S K Pandey; J L Chiasson; A K Srivastava
Journal:  Mol Cell Biochem       Date:  1995 Dec 6-20       Impact factor: 3.396

4.  Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA.

Authors:  M Miralpeix; E Carballo; R Bartrons; K Crepin; L Hue; G G Rousseau
Journal:  Diabetologia       Date:  1992-03       Impact factor: 10.122

  4 in total

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