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Literature DB >> 25426824

Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats.

Yumei Guo¹, Zhuo Wang, Emeran A Mayer, Daniel P Holschneider.

Abstract

Early life stress is a risk factor for developing functional pain disorders. The 'limited bedding' (LB) model elicits psychological stress in the dam and her pups by providing minimal nesting material following delivery. Little is known about the effects of LB on visceral pain. Rats (female, male) were exposed to LB on postnatal days 2-9. Electromyographic visceromotor responses were recorded at the age of 11-12 weeks during titrated colorectal distension. LB exposure resulted in significant visceral hyperalgesia in both sexes. Sex differences were demonstrated only in nonstressed controls, with females showing a greater visceromotor response. Our results prepare the way for use of the LB model in studying the development of visceral pain in adults with functional gastrointestinal disorders.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 25426824 PMCID： PMC4246414 DOI： 10.1097/WNR.0000000000000292

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

24 in total

1. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat.

Authors: S V Coutinho; P M Plotsky; M Sablad; J C Miller; H Zhou; A I Bayati; J A McRoberts; E A Mayer
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2002-02 Impact factor: 4.052

2. A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge secretion of luteinizing hormone in the rat.

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Journal: Endocrinology Date: 1978-01 Impact factor: 4.736

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Journal: Pediatr Neurol Date: 1996-09 Impact factor: 3.372

4. Assessment of visceral sensitivity using radio telemetry in a rat model of maternal separation.

Authors: O Welting; R M Van Den Wijngaard; W J De Jonge; R Holman; G E Boeckxstaens
Journal: Neurogastroenterol Motil Date: 2005-12 Impact factor: 3.598

5. Altered regulation of gene and protein expression of hypothalamic-pituitary-adrenal axis components in an immature rat model of chronic stress.

Authors: S Avishai-Eliner; E E Gilles; M Eghbal-Ahmadi; Y Bar-El; T Z Baram
Journal: J Neuroendocrinol Date: 2001-09 Impact factor: 3.627

6. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors.

Authors: Autumn S Ivy; Christopher S Rex; Yuncai Chen; Céline Dubé; Pamela M Maras; Dimitri E Grigoriadis; Christine M Gall; Gary Lynch; Tallie Z Baram
Journal: J Neurosci Date: 2010-09-29 Impact factor: 6.167

7. Estrous cycle phase variations in visceromotor and cardiovascular responses to colonic distension in the anesthetized rat.

Authors: S Sapsed-Byrne; D Ma; D Ridout; A Holdcroft
Journal: Brain Res Date: 1996-12-02 Impact factor: 3.252

8. Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability.

Authors: F Ochoa-Cortes; R Guerrero-Alba; E E Valdez-Morales; I Spreadbury; C Barajas-Lopez; M Castro; J Bertrand; N Cenac; N Vergnolle; S J Vanner
Journal: Neurogastroenterol Motil Date: 2013-11-29 Impact factor: 3.598

9. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.

Authors: Sylvie Bradesi; Ines Schwetz; Helena S Ennes; Christophe M R Lamy; Gordon Ohning; Michael Fanselow; Charalabos Pothoulakis; James A McRoberts; Emeran A Mayer
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10. Anger and childhood sexual abuse are independently associated with irritable bowel syndrome.

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13 in total

1. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.

Authors: Claire-Dominique Walker; Kevin G Bath; Marian Joels; Aniko Korosi; Muriel Larauche; Paul J Lucassen; Margaret J Morris; Charlis Raineki; Tania L Roth; Regina M Sullivan; Yvette Taché; Tallie Z Baram
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2. Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation.

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Journal: Lab Anim (NY) Date: 2017-03-22 Impact factor: 12.625

Review 3. Early-life adversity, epigenetics, and visceral hypersensitivity.

Authors: S Liu; S I Hagiwara; A Bhargava
Journal: Neurogastroenterol Motil Date: 2017-09 Impact factor: 3.598

4. Gabapentin Improves Oral Feeding in Neurologically Intact Infants With Abdominal Disorders.

Authors: Keliana L O'Mara; Saleem Islam; Janice A Taylor; Daniel Solomon; Michael D Weiss
Journal: J Pediatr Pharmacol Ther Date: 2018 Jan-Feb

5. Early life adversity in piglets induces long-term upregulation of the enteric cholinergic nervous system and heightened, sex-specific secretomotor neuron responses.

Authors: J E Medland; C S Pohl; L L Edwards; S Frandsen; K Bagley; Y Li; A J Moeser
Journal: Neurogastroenterol Motil Date: 2016-05-02 Impact factor: 3.598

Review 6. Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.

Authors: Calvin S Pohl; Julia E Medland; Adam J Moeser
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2015-10-08 Impact factor: 4.052