Literature DB >> 2542677

Clinical significance of serum guanase activity in various liver diseases.

G Shiota1, J Fukada, T Ito, M Tsukizawa, M Yamada, M Sato.   

Abstract

Serum guanase activity was measured using a sensitive colorimetric method in patients with liver diseases. Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases. In addition, the GPT-to-guanase ratio differed chronic hepatitis from liver cirrhosis. These findings suggest that determination of guanase and aminotransferases in useful in differentiation of liver diseases as well as assessing liver damage.

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Year:  1989        PMID： 2542677     DOI： 10.2169/internalmedicine1962.28.22

Source DB:  PubMed          Journal:  Jpn J Med        ISSN： 0021-5120


  3 in total

1.  A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition.

Authors:  Saibal Chakraborty; Niti H Shah; James C Fishbein; Ramachandra S Hosmane
Journal:  Bioorg Med Chem Lett       Date:  2010-11-27       Impact factor: 2.823

2.  Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.

Authors:  José R Fernández; Eric S Sweet; William J Welsh; Bonnie L Firestein
Journal:  Bioorg Med Chem       Date:  2010-07-27       Impact factor: 3.641

3.  Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.

Authors:  Saritha Tantravedi; Saibal Chakraborty; Niti H Shah; James C Fishbein; Ramachandra S Hosmane
Journal:  Bioorg Med Chem       Date:  2013-07-11       Impact factor: 3.641
  3 in total

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