Michal Lipinski1, Alicja Rydzewska-Rosolowska, Andrzej Rydzewski, Grazyna Rydzewska. 1. From the *Department of Gastroenterology, Central Clinical Hospital of the Ministry of Interior, Warsaw; †Department of Nephrology and Transplantation, Medical University of Bialystok, Bialystok; ‡Department of Internal Medicine and Nephrology, Central Clinical Hospital of the Ministry of Interior, Warsaw; and §Faculty of Health Sciences, Uniwersytet Jana Kochanowskiego w Kielcach, Kielce, Poland.
Abstract
OBJECTIVES: In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a useful marker of AP severity. METHODS: We observed a cohort of 104 prospectively enrolled patients. The patients were classified into 3 groups: mild AP, moderately severe AP, and severe AP. Urine samples were collected on admission (NGAL-as) and during the first 24 hours (NGAL-first day) for examination of urinary level of NGAL concentrations from the first day. RESULTS: Acute pancreatitis was considered severe in 16 (15%) patients, moderately severe in 25 (24%) patients, and mild in 63 (61%) patients.There were statistically significant trends for an increase in severity (P = 0.04, P = 0.003) and mortality (P < 0.031, P = 0.01) with raising NGAL-as and NGAL-first day concentrations, respectively. The areas under the curve for severity predicted by NGAL-as and NGAL-first day were 0.75 and 0.93, respectively. The areas under the curve for mortality prediction by NGAL-as and NGAL-first day were 0.980 and 0.92, respectively. CONCLUSIONS: The urinary level of NGAL is a promising new diagnostic and prognostic factor for severe AP in an early stage of the disease.
OBJECTIVES: In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a useful marker of AP severity. METHODS: We observed a cohort of 104 prospectively enrolled patients. The patients were classified into 3 groups: mild AP, moderately severe AP, and severe AP. Urine samples were collected on admission (NGAL-as) and during the first 24 hours (NGAL-first day) for examination of urinary level of NGAL concentrations from the first day. RESULTS:Acute pancreatitis was considered severe in 16 (15%) patients, moderately severe in 25 (24%) patients, and mild in 63 (61%) patients.There were statistically significant trends for an increase in severity (P = 0.04, P = 0.003) and mortality (P < 0.031, P = 0.01) with raising NGAL-as and NGAL-first day concentrations, respectively. The areas under the curve for severity predicted by NGAL-as and NGAL-first day were 0.75 and 0.93, respectively. The areas under the curve for mortality prediction by NGAL-as and NGAL-first day were 0.980 and 0.92, respectively. CONCLUSIONS: The urinary level of NGAL is a promising new diagnostic and prognostic factor for severe AP in an early stage of the disease.
Authors: Kristyn Gumpper; Andrew William Dangel; Valentina Pita-Grisanti; Somashekar G Krishna; Luis F Lara; Thomas Mace; Georgios I Papachristou; Darwin L Conwell; Phil A Hart; Zobeida Cruz-Monserrate Journal: Pancreatology Date: 2020-01-07 Impact factor: 3.996
Authors: Mariusz Rosołowski; Michał Lipiński; Marek Dobosz; Marek Durlik; Stanisław Głuszek; Katarzyna Kuśnierz; Paweł Lampe; Ewa Małecka-Panas; Ewa Nowakowska-Duława; Magdalena Nowak-Niezgoda; Barbara Radomańska; Renata Talar-Wojnarowska; Urszula Wereszczyńska-Siemiątkowska; Grażyna Rydzewska Journal: Prz Gastroenterol Date: 2016-06-08