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Literature DB >> 2542605

Antigen-presenting liposomes are effective in treatment of recurrent herpes simplex virus genitalis in guinea pigs.

Abstract

The therapeutic and immunologic effects of a liposome preparation containing both a macrophage activator, muramyl-tripeptide-phosphatidylethanolamine, and a recombinant antigen, glycoprotein D of herpes simplex virus type 1, have been investigated. This preparation was tested in vitro for the ability to stimulate peripheral blood lymphocytes and in vivo for the control of recurrent herpes genitalis in guinea pigs. Our results show that the liposome-antigen-adjuvant preparation is capable of enhancing antigen-specific lymphocyte stimulation, which may be related to the observed 75% suppression of the frequency and severity of reactivation of recurrent herpes simplex virus type 2 genitalis compared with that of placebo controls.

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Year: 1989 PMID： 2542605 PMCID： PMC250849

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

32 in total

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Journal: Nature Date: 1976-03-25 Impact factor: 49.962

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Authors: S E Straus; H E Takiff; M Seidlin; S Bachrach; L Lininger; J J DiGiovanna; K A Western; H A Smith; S N Lehrman; T Creagh-Kirk
Journal: N Engl J Med Date: 1984-06-14 Impact factor: 91.245

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Journal: Clin Immunol Immunopathol Date: 1981-05

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Authors: A Adam; J F Petit; P Lefrancier; E Lederer
Journal: Mol Cell Biochem Date: 1981-12-04 Impact factor: 3.396

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Authors: A L Cunningham; P A Nelson; C G Fathman; T C Merigan
Journal: J Gen Virol Date: 1985-02 Impact factor: 3.891

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Authors: L Sanchez-Pescador; R L Burke; G Ott; G Van Nest
Journal: J Immunol Date: 1988-09-01 Impact factor: 5.422

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Authors: J M Douglas; C Critchlow; J Benedetti; G J Mertz; J D Connor; M A Hintz; A Fahnlander; M Remington; C Winter; L Corey
Journal: N Engl J Med Date: 1984-06-14 Impact factor: 91.245

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Authors: L R Stanberry; E R Kern; J T Richards; T M Abbott; J C Overall
Journal: J Infect Dis Date: 1982-09 Impact factor: 5.226

9. Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects.

Authors: Y J Bryson; M Dillon; M Lovett; G Acuna; S Taylor; J D Cherry; B L Johnson; E Wiesmeier; W Growdon; T Creagh-Kirk; R Keeney
Journal: N Engl J Med Date: 1983-04-21 Impact factor: 91.245

10. gamma Interferon production appears to predict time of recurrence of herpes labialis.

Authors: A L Cunningham; T C Merigan
Journal: J Immunol Date: 1983-05 Impact factor: 5.422

7 in total

1. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs.

Authors: Yo Hoshino; Sarat K Dalai; Kening Wang; Lesley Pesnicak; Tsz Y Lau; David M Knipe; Jeffrey I Cohen; Stephen E Straus
Journal: J Virol Date: 2005-01 Impact factor: 5.103

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Authors: J J Bergers; T L ten Hagen; E W van Etten; I A Bakker-Woudenberg
Journal: Pharm World Sci Date: 1995-01-27

3. Human immunodeficiency virus-like, nonreplicating, gag-env particles assemble in a recombinant vaccinia virus expression system.

Authors: O Haffar; J Garrigues; B Travis; P Moran; J Zarling; S L Hu
Journal: J Virol Date: 1990-06 Impact factor: 5.103

4. Vaccine therapy for ocular herpes simplex virus (HSV) infection: periocular vaccination reduces spontaneous ocular HSV type 1 shedding in latently infected rabbits.

Authors: A B Nesburn; R L Burke; H Ghiasi; S Slanina; S Bahri; S L Wechsler
Journal: J Virol Date: 1994-08 Impact factor: 5.103