Sir,I read with interest article entitled “evaluation of the role of antibiotics in preventing postoperative complications after routine periodontal surgery: A comparative clinical study” authored by Dr. Mohan et al.[1] in the March-April 2014 issue of Journal of Indian Society of Periodontology.The authors have suggested that antibiotic administration is not required after routine periodontal surgery which is quite appreciable. Similar findings were reported by Powell et al.[2] who suggested that there may be no benefit in prescribing antibiotics for the sole purpose of preventing postoperative infections. Abu-Ta’a et al.[3] have speculated that antibiotic use may not be effective in preventing postoperative infections in aseptic conditions, but they significantly reduce the postoperative discomfort.In spite of knowing the effects of indiscriminate prescription of antibiotics, we periodontists are prescribing it on a day to day basis to our patients. This practice cannot be considered totally wrong as strict asepsis in an Indian setting may be possible for a clinical study, but attaining it in every patient is a goal we dream to achieve. However, an antibiotic regimen regarding which antibiotic should be preferred where required and the duration of the prescription is the need of the hour to prevent the overuse of these life-saving drugs.