Literature DB >> 25425464

MicroRNAs regulate immune system via multiple targets.

Sujie Jia1, Hanyue Zhai2, Ming Zhao2.   

Abstract

MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression. Each miRNA may suppress multiple mRNA targets, while one mRNA can be targeted by many miRNAs for precise control of a wide range of cellular processes. The important role of miRNAs in the immune system is highlighted by the conditional Dicer knockout mouse, which exhibited profound aberrant development and function of immune cells. One particular miRNA, miR-155, is highly expressed and plays important role in lymphocytes. In this review we focused on the role of miRNA, especially miR-155, via their predicted and known mRNA targets in innate and adaptive immunity. Finally, we discussed the potential of miRNAs as novel targets for the diagnosis and therapy of immune system diseases.

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Year:  2014        PMID： 25425464

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  19 in total

1.  EBV microRNA-BHRF1-2-5p targets the 3'UTR of immune checkpoint ligands PD-L1 and PD-L2.

Authors:  Alexandre S Cristino; Jamie Nourse; Rachael A West; Muhammed Bilal Sabdia; Soi C Law; Jay Gunawardana; Frank Vari; Sally Mujaj; Gayathri Thillaiyampalam; Cameron Snell; Madeline Gough; Colm Keane; Maher K Gandhi
Journal:  Blood       Date:  2019-12-19       Impact factor: 22.113

2.  Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects.

Authors:  Afsar R Naqvi; Maria F Brambila; Gloria Martínez; Gabriela Chapa; Salvador Nares
Journal:  J Clin Periodontol       Date:  2019-01       Impact factor: 8.728

Review 3.  Deregulation and therapeutic potential of microRNAs in arthritic diseases.

Authors:  Rita Vicente; Danièle Noël; Yves-Marie Pers; Florence Apparailly; Christian Jorgensen
Journal:  Nat Rev Rheumatol       Date:  2015-12-24       Impact factor: 20.543

4.  Feeding of Enterococcus faecium NCIMB 10415 Leads to Intestinal miRNA-423-5p-Induced Regulation of Immune-Relevant Genes.

Authors:  Susanne Kreuzer-Redmer; Jennifer C Bekurtz; Danny Arends; Ralf Bortfeldt; Barbara Kutz-Lohroff; Soroush Sharbati; Ralf Einspanier; Gudrun A Brockmann
Journal:  Appl Environ Microbiol       Date:  2016-04-04       Impact factor: 4.792

Review 5.  Selenium targets resistance biomarkers enhancing efficacy while reducing toxicity of anti-cancer drugs: preclinical and clinical development.

Authors:  Yousef Zakharia; Arup Bhattacharya; Youcef M Rustum
Journal:  Oncotarget       Date:  2018-01-23

6.  Cadherin 6 is activated by Epstein-Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma.

Authors:  L-L Zuo; J Zhang; L-Z Liu; Q Zhou; S-J Du; S-Y Xin; Z-P Ning; J Yang; H-B Yu; W-X Yue; J Wang; F-X Zhu; G-Y Li; J-H Lu
Journal:  Oncogenesis       Date:  2017-12-22       Impact factor: 6.524

Review 7.  Small and Smaller-sRNAs and MicroRNAs in the Regulation of Toxin Gene Expression in Prokaryotic Cells: A Mini-Review.

Authors:  Sylwia Bloch; Alicja Węgrzyn; Grzegorz Węgrzyn; Bożena Nejman-Faleńczyk
Journal:  Toxins (Basel)       Date:  2017-05-30       Impact factor: 4.546

Review 8.  Epstein-Barr virus-encoded microRNAs as regulators in host immune responses.

Authors:  Man Wang; Fei Yu; Wei Wu; Yu Wang; Han Ding; Lili Qian
Journal:  Int J Biol Sci       Date:  2018-04-05       Impact factor: 6.580

9.  MicroRNAs: The Role in Autoimmune Inflammation.

Authors:  N M Baulina; O G Kulakova; O O Favorova
Journal:  Acta Naturae       Date:  2016 Jan-Mar       Impact factor: 1.845

10.  Impact of adipose tissue or umbilical cord derived mesenchymal stem cells on the immunogenicity of human cord blood derived endothelial progenitor cells.

Authors:  Kefang Tan; Ke Zheng; Daiye Li; Haiyuan Lu; Siqi Wang; Xuan Sun
Journal:  PLoS One       Date:  2017-05-31       Impact factor: 3.240
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