Fengying Wu1, Chunxia Su1, Li Liu1, Jianfang Xu1. 1. Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Abstract
BACKGROUND AND AIM: Hyperpigmentation is a kind of paraneoplastic syndrome associated with lung cancer. Diffuse hyperpigmentation was reported and generally resulted from overproduction of melanocyte-stimulating hormone or adrenocorticotropic hormone. However, localized hyperpigmentation is rare for lung cancer. METHODS: Here, we report a 56-year-old lung adenocarcinoma patient who developed hyperpigmentation in two palms about 3 months preceding the diagnosis and resolved gradually with the shrink of the primary tumours in lung after chemotherapy. RESULT: Localized hyperpigmentation suggests that another mechanism might be involved. CONCLUSION: The case reminds us that any skin disorders without obvious causes in heavy smokers should be alerted as a sign of lung cancer and sometimes could be used as a marker of response to the treatment.
BACKGROUND AND AIM: Hyperpigmentation is a kind of paraneoplastic syndrome associated with lung cancer. Diffuse hyperpigmentation was reported and generally resulted from overproduction of melanocyte-stimulating hormone or adrenocorticotropic hormone. However, localized hyperpigmentation is rare for lung cancer. METHODS: Here, we report a 56-year-old lung adenocarcinomapatient who developed hyperpigmentation in two palms about 3 months preceding the diagnosis and resolved gradually with the shrink of the primary tumours in lung after chemotherapy. RESULT: Localized hyperpigmentation suggests that another mechanism might be involved. CONCLUSION: The case reminds us that any skin disorders without obvious causes in heavy smokers should be alerted as a sign of lung cancer and sometimes could be used as a marker of response to the treatment.