Literature DB >> 25425197

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation.

F De Falco1, R Sabatini1, F Falzetti2, M Di Ianni3, P Sportoletti2, S Baldoni2, B Del Papa2, I Screpanti4, P Marconi1, E Rosati1.   

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Year:  2014        PMID： 25425197     DOI： 10.1038/leu.2014.329

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


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  16 in total

1.  NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL.

Authors:  Paolo Sportoletti; Stefano Baldoni; Laura Cavalli; Beatrice Del Papa; Elisabetta Bonifacio; Raffaella Ciurnelli; Alain Sylvin Bell; Ambra Di Tommaso; Emanuela Rosati; Barbara Crescenzi; Cristina Mecucci; Isabella Screpanti; Pierfrancesco Marconi; Massimo F Martelli; Mauro Di Ianni; Franca Falzetti
Journal:  Br J Haematol       Date:  2010-08-31       Impact factor: 6.998

2.  Glycogen synthase kinase 3-β phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization.

Authors:  Xiangzi Han; Ji-hyun Ju; Incheol Shin
Journal:  Biochem Biophys Res Commun       Date:  2012-05-26       Impact factor: 3.575

3.  A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia.

Authors:  P Sportoletti; S Baldoni; B Del Papa; P Aureli; E Dorillo; L Ruggeri; S Plebani; V Amico; A Di Tommaso; E Rosati; P Marconi; M Di Ianni; F Falzetti
Journal:  Leukemia       Date:  2013-10-09       Impact factor: 11.528

Review 4.  Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.

Authors:  Adrian Wiestner
Journal:  Blood       Date:  2012-08-08       Impact factor: 22.113

5.  Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity.

Authors:  Prathibha Ranganathan; Rodrigo Vasquez-Del Carpio; Fred M Kaplan; Hong Wang; Ashu Gupta; Jeffrey D VanWye; Anthony J Capobianco
Journal:  J Biol Chem       Date:  2011-06-17       Impact factor: 5.157

6.  Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

Authors:  Medhat Shehata; Susanne Schnabl; Dita Demirtas; Martin Hilgarth; Rainer Hubmann; Elena Ponath; Sigrun Badrnya; Claudia Lehner; Andrea Hoelbl; Markus Duechler; Alexander Gaiger; Christoph Zielinski; Josef D Schwarzmeier; Ulrich Jaeger
Journal:  Blood       Date:  2010-06-24       Impact factor: 22.113

7.  Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.

Authors:  J C Aster; E S Robertson; R P Hasserjian; J R Turner; E Kieff; J Sklar
Journal:  J Biol Chem       Date:  1997-04-25       Impact factor: 5.157

8.  Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells.

Authors:  Andrei V Ougolkov; Nancy D Bone; Martin E Fernandez-Zapico; Neil E Kay; Daniel D Billadeau
Journal:  Blood       Date:  2007-04-26       Impact factor: 22.113

9.  Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

Authors:  Christy J Fryer; J Brandon White; Katherine A Jones
Journal:  Mol Cell       Date:  2004-11-19       Impact factor: 17.970

10.  Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

Authors:  W S Pear; J C Aster; M L Scott; R P Hasserjian; B Soffer; J Sklar; D Baltimore
Journal:  J Exp Med       Date:  1996-05-01       Impact factor: 14.307
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  6 in total

1.  Network-Based Integration of Disparate Omic Data To Identify "Silent Players" in Cancer.

Authors:  Matthew Ruffalo; Mehmet Koyutürk; Roded Sharan
Journal:  PLoS Comput Biol       Date:  2015-12-18       Impact factor: 4.475

2.  NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells.

Authors:  Mauro Di Ianni; Stefano Baldoni; Beatrice Del Papa; Patrizia Aureli; Erica Dorillo; Filomena De Falco; Elisa Albi; Emanuela Varasano; Ambra Di Tommaso; Raffaella Giancola; Patrizia Accorsi; Gianluca Rotta; Chiara Rompietti; Estevão Carlos Silva Barcelos; Antonio Francesco Campese; Paolo Di Bartolomeo; Isabella Screpanti; Emanuela Rosati; Franca Falzetti; Paolo Sportoletti
Journal:  Front Oncol       Date:  2018-04-20       Impact factor: 6.244

3.  Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.

Authors:  Stefano Baldoni; Beatrice Del Papa; Erica Dorillo; Patrizia Aureli; Filomena De Falco; Chiara Rompietti; Daniele Sorcini; Emanuela Varasano; Debora Cecchini; Tiziana Zei; Ambra Di Tommaso; Emanuela Rosati; Gabriela Alexe; Giovanni Roti; Kimberly Stegmaier; Mauro Di Ianni; Franca Falzetti; Paolo Sportoletti
Journal:  Int J Cancer       Date:  2018-03-23       Impact factor: 7.396

4.  IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation.

Authors:  Filomena De Falco; Beatrice Del Papa; Stefano Baldoni; Rita Sabatini; Franca Falzetti; Mauro Di Ianni; Maria Paola Martelli; Federica Mezzasoma; Maria Pelullo; Pierfrancesco Marconi; Paolo Sportoletti; Isabella Screpanti; Emanuela Rosati
Journal:  Cell Death Dis       Date:  2018-11-26       Impact factor: 8.469

5.  GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL.

Authors:  Paolo Sportoletti; Emanuela Rosati; Filomena De Falco; Chiara Rompietti; Daniele Sorcini; Angela Esposito; Annarita Scialdone; Stefano Baldoni; Beatrice Del Papa; Francesco Maria Adamo; Estevão Carlos Silva Barcelos; Erica Dorillo; Arianna Stella; Mauro Di Ianni; Isabella Screpanti
Journal:  Cell Death Dis       Date:  2022-09-01       Impact factor: 9.685

Review 6.  NOTCH1 Aberrations in Chronic Lymphocytic Leukemia.

Authors:  Emanuela Rosati; Stefano Baldoni; Filomena De Falco; Beatrice Del Papa; Erica Dorillo; Chiara Rompietti; Elisa Albi; Franca Falzetti; Mauro Di Ianni; Paolo Sportoletti
Journal:  Front Oncol       Date:  2018-06-27       Impact factor: 6.244
  6 in total

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